(S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-oxo-5-phenyl-2-(triphenyl-λ⁵-phosphanylidene)-pentanoic acid benzyl ester

Base Information

• Chemical Name: (S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-oxo-5-phenyl-2-(triphenyl-λ⁵-phosphanylidene)-pentanoic acid benzyl ester
• CAS No.: 186961-85-3
• Molecular Formula: C₅₆H₆₀N₃O₇P
• Molecular Weight: 918.082

Synonyms:

Chemical Property of (S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-oxo-5-phenyl-2-(triphenyl-λ⁵-phosphanylidene)-pentanoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of (S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-oxo-5-phenyl-2-(triphenyl-λ⁵-phosphanylidene)-pentanoic acid benzyl ester

There total 4 articles about (S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-oxo-5-phenyl-2-(triphenyl-λ⁵-phosphanylidene)-pentanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → (S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-oxo-5-phenyl-2-(triphenyl-λ5-phosphanylidene)-pentanoic acid benzyl ester (186961-85-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent

2: TFA

3: EDC, HOBt

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid;

DOI:10.1016/S0960-894X(96)00559-8

Reference yield:

(carbobenzyloxymethylene)triphenylphosphorane (15097-38-8) → (S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-oxo-5-phenyl-2-(triphenyl-λ5-phosphanylidene)-pentanoic acid benzyl ester (186961-85-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent

2: TFA

3: EDC, HOBt

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid;

DOI:10.1016/S0960-894X(96)00559-8

Reference yield:

(S)-4-tert-Butoxycarbonylamino-3-oxo-5-phenyl-2-(triphenyl-λ5-phosphanylidene)-pentanoic acid benzyl ester (186961-84-2) → (S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-oxo-5-phenyl-2-(triphenyl-λ5-phosphanylidene)-pentanoic acid benzyl ester (186961-85-3)

Guidance literature:

Multi-step reaction with 2 steps

1: TFA

2: EDC, HOBt

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid;

DOI:10.1016/S0960-894X(96)00559-8

upstream raw materials:

N-benzyloxycarbonyl-L-leucyl-L-leucine

N-tert-butoxycarbonyl-L-phenylalanine

(carbobenzyloxymethylene)triphenylphosphorane

(S)-4-tert-Butoxycarbonylamino-3-oxo-5-phenyl-2-(triphenyl-λ⁵-phosphanylidene)-pentanoic acid benzyl ester

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