3-Amino-2-butenoic acid tert-butyl ester

Base Information

• Chemical Name: 3-Amino-2-butenoic acid tert-butyl ester
• CAS No.: 14205-43-7
• Molecular Formula: C8H15NO2
• Molecular Weight: 157.213
• Hs Code.: 2922499990
• Mol file: 14205-43-7.mol

Synonyms:3-Amino-2-butenoic acid tert-butyl ester;tert-butyl 3-aminocrotonate;2-Butenoic acid,3-amino-,1,1-dimethylethyl ester;3-amino crotonic acid-tert. butylester;

Chemical Property of 3-Amino-2-butenoic acid tert-butyl ester

Chemical Property:

• Melting Point: 37-39 °C(Solv: hexane (110-54-3))
• Boiling Point: 60 °C(Press: 0.4 Torr)
• PKA: 5.32±0.70(Predicted)
• PSA: 52.32000
• Density: 0.975±0.06 g/cm3(Predicted)
• LogP: 1.89090

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-2-butenoic acid tert-butyl ester

There total 2 articles about 3-Amino-2-butenoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl acetoacetate (1694-31-1) → tert-butyl 3-aminocrotonate (14205-43-7)

Guidance literature:

With ammonia; In methanol; water; at 20 ℃; for 14h;

Reference yield:

→ tert-butyl 3-aminocrotonate (14205-43-7)

Guidance literature:

Reference yield: 93.0%

2-(bromomethyl)quinazolin-4(3H)-one (19062-51-2) + tert-butyl 3-aminocrotonate (14205-43-7) + 4-Methoxyphenyl isothiocyanate (2284-20-0) → C25H25N3O4S (1255216-20-6)

Guidance literature:

tert-butyl 3-aminocrotonate; 4-Methoxyphenyl isothiocyanate; In tetrahydrofuran; acetonitrile; at 45 - 50 ℃; for 5 - 6h;

2-(bromomethyl)quinazolin-4(3H)-one; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 3 - 4h;

DOI:10.1016/j.tetlet.2010.08.046

upstream raw materials:

tert-butyl acetoacetate

Downstream raw materials:

3-Amino-2-phenylazo-2-butensaeure-tert-butylester

3-Amino-2-(2,4,6-trimethylphenylazo)-2-butensaeure-tert-butylester

tert-butyl 2-dimethoxymethyl-3-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-5-carboxylate

2,6-Dimethyl-4-(2-nitro-phenyl)-5-(2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-1,4-dihydro-pyridine-3-carboxylic acid tert-butyl ester