(S)-2-benzyloxycarbonylamino-4-oxo-4-phenyl-butanoyl pyrrolidine

Base Information

• Chemical Name: (S)-2-benzyloxycarbonylamino-4-oxo-4-phenyl-butanoyl pyrrolidine
• CAS No.: 221122-70-9
• Molecular Formula: C₂₂H₂₄N₂O₄
• Molecular Weight: 380.444
• Mol file: 221122-70-9.mol

Synonyms:

Chemical Property of (S)-2-benzyloxycarbonylamino-4-oxo-4-phenyl-butanoyl pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-benzyloxycarbonylamino-4-oxo-4-phenyl-butanoyl pyrrolidine

There total 4 articles about (S)-2-benzyloxycarbonylamino-4-oxo-4-phenyl-butanoyl pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → (S)-2-benzyloxycarbonylamino-4-oxo-4-phenyl-butanoyl pyrrolidine (221122-70-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / aq. NaOH / 48 h / Ambient temperature

2: 1.) TBTU, EtN(i-Pr)2 / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) CH₂Cl₂, 0 deg C

With sodium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;

DOI:10.1016/S0957-4166(98)00472-8

Reference yield:

(S)-2-amino-4-oxo-4-phenyl-butanoic acid (119817-54-8) → (S)-2-benzyloxycarbonylamino-4-oxo-4-phenyl-butanoyl pyrrolidine (221122-70-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / aq. NaOH / 48 h / Ambient temperature

2: 1.) TBTU, EtN(i-Pr)2 / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) CH₂Cl₂, 0 deg C

With sodium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;

DOI:10.1016/S0957-4166(98)00472-8

Reference yield:

(S)-2-trifluoroacetylamino-4-oxo-4-phenyl-butanoic acid (200730-99-0) → (S)-2-benzyloxycarbonylamino-4-oxo-4-phenyl-butanoyl pyrrolidine (221122-70-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / aq. NaOH / 4 h / 0 °C

2: 75 percent / aq. NaOH / 48 h / Ambient temperature

3: 1.) TBTU, EtN(i-Pr)2 / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) CH₂Cl₂, 0 deg C

With sodium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;

DOI:10.1016/S0957-4166(98)00472-8

upstream raw materials:

pyrrolidine

(S)-2-benzyloxycarbonylamino-4-oxo-4-phenyl-butanoic acid

benzyl chloroformate

(S)-2-amino-4-oxo-4-phenyl-butanoic acid