4-{[(S)-2-((3S,4S)-4-Amino-3-hydroxy-5-phenyl-pentanoylamino)-3-methyl-butyrylamino]-methyl}-benzoic acid methyl ester

Base Information

• Chemical Name: 4-{[(S)-2-((3S,4S)-4-Amino-3-hydroxy-5-phenyl-pentanoylamino)-3-methyl-butyrylamino]-methyl}-benzoic acid methyl ester
• CAS No.: 731860-40-5
• Molecular Formula: C₂₅H₃₃N₃O₅
• Molecular Weight: 455.554
• Mol file: 731860-40-5.mol

Synonyms:

Chemical Property of 4-{[(S)-2-((3S,4S)-4-Amino-3-hydroxy-5-phenyl-pentanoylamino)-3-methyl-butyrylamino]-methyl}-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{[(S)-2-((3S,4S)-4-Amino-3-hydroxy-5-phenyl-pentanoylamino)-3-methyl-butyrylamino]-methyl}-benzoic acid methyl ester

There total 5 articles about 4-{[(S)-2-((3S,4S)-4-Amino-3-hydroxy-5-phenyl-pentanoylamino)-3-methyl-butyrylamino]-methyl}-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-{[(S)-2-((3S,4S)-4-tert-Butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoylamino)-3-methyl-butyrylamino]-methyl}-benzoic acid methyl ester → 4-{[(S)-2-((3S,4S)-4-Amino-3-hydroxy-5-phenyl-pentanoylamino)-3-methyl-butyrylamino]-methyl}-benzoic acid methyl ester (731860-40-5)

Guidance literature:

With trifluoroacetic acid;

DOI:10.1016/j.bmcl.2004.04.068

Reference yield:

t-Boc-L-valine (13734-41-3) → 4-{[(S)-2-((3S,4S)-4-Amino-3-hydroxy-5-phenyl-pentanoylamino)-3-methyl-butyrylamino]-methyl}-benzoic acid methyl ester (731860-40-5)

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethyl-N'-(dimethylaminopropyl)carbodiimide hydrochloride

2: TFA

3: N-ethyl-N'-(dimethylaminopropyl)carbodiimide hydrochloride

4: TFA

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid;

DOI:10.1016/j.bmcl.2004.04.068

Reference yield:

methyl 4-(aminomethyl)benzoate hydrochloride (6232-11-7) → 4-{[(S)-2-((3S,4S)-4-Amino-3-hydroxy-5-phenyl-pentanoylamino)-3-methyl-butyrylamino]-methyl}-benzoic acid methyl ester (731860-40-5)

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethyl-N'-(dimethylaminopropyl)carbodiimide hydrochloride

2: TFA

3: N-ethyl-N'-(dimethylaminopropyl)carbodiimide hydrochloride

4: TFA

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid;

DOI:10.1016/j.bmcl.2004.04.068

upstream raw materials:

t-Boc-L-valine

methyl 4-(aminomethyl)benzoate hydrochloride

Downstream raw materials:

4-({(S)-2-[(3S,4S)-4-((3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoylamino)-3-hydroxy-5-phenyl-pentanoylamino]-3-methyl-butyrylamino}-methyl)-benzoic acid methyl ester