7-Fluoro-3-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)ben zodiazepine

Base Information

Chemical Name:7-Fluoro-3-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)ben zodiazepine
CAS No.:74162-37-1
Molecular Formula:C₁₇H₁₉FN₄S
Molecular Weight:330.429
Hs Code.:
Mol file:74162-37-1.mol

Synonyms:7-Fluoro-3-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)ben zodiazepine

Suppliers and Price of 7-Fluoro-3-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)ben zodiazepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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American Custom Chemicals Corporation
7-FLUORO-3-METHYL-4-(4-METHYL-1-PIPERAZINYL)-10H-THIENO(2,3-B)(1,5)BEN ZODIAZEPINE 95.00%
5MG
$ 499.63

Total 0 raw suppliers

Chemical Property of 7-Fluoro-3-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)ben zodiazepine

Chemical Property:

Vapor Pressure:2.25E-08mmHg at 25°C
Melting Point:209-210 °C(Solv: acetonitrile (75-05-8))
Boiling Point:452.4°C at 760 mmHg
PKA:7.37±0.20(Predicted)
Flash Point:227.4°C
PSA：59.11000
Density:1.38g/cm³
LogP:1.33490

Purity/Quality:: 7-FLUORO-3-METHYL-4-(4-METHYL-1-PIPERAZINYL)-10H-THIENO(2,3-B)(1,5)BEN ZODIAZEPINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 7-Fluoro-3-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)ben zodiazepine

There total 3 articles about 7-Fluoro-3-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)ben zodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 109-01-3
1-methyl-piperazine

: 7-Fluoro-1-methyl-4,9-dihydro-3-thia-4,9-diaza-benzo[f]azulen-10-one

: 74162-37-1
7-fluoro-3-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno<2,3-b><1,5>benzodiazepine

Guidance literature:: With titanium tetrachloride; In various solvent(s); at 120 ℃; for 2h;
DOI:10.1021/jm00182a013

Reference yield:

: 74162-68-8
ethyl 2-(4-fluoro-2-nitroanilino)-4-methylthiophene-3-carboxylate

: 74162-37-1
7-fluoro-3-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno<2,3-b><1,5>benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / 10percent Pd/C / ethanol; ethyl acetate / 3102.9 Torr

2: TiCl₄ / various solvent(s) / 1.) 120 deg C, 4 h, 2.) reflux, overnight

With hydrogen; titanium tetrachloride; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1021/jm00182a013

Reference yield:

: 109-01-3
1-methyl-piperazine

: 2-(2-Amino-4-fluoro-phenylamino)-4-methyl-thiophene-3-carboxylic acid ethyl ester

: 74162-37-1
7-fluoro-3-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno<2,3-b><1,5>benzodiazepine

Guidance literature:: With titanium tetrachloride; In various solvent(s); Yield given; 1.) 120 deg C, 4 h, 2.) reflux, overnight;
DOI:10.1021/jm00182a013