5-Hydroxymethyl-2-thiophene carbocylic acid

Base Information

• Chemical Name: 5-Hydroxymethyl-2-thiophene carbocylic acid
• CAS No.: 14282-64-5
• Molecular Formula: C6H6O3S
• Molecular Weight: 158.178
• Mol file: 14282-64-5.mol

Synonyms:5-Hydroxymethyl-thiophen-2-carbonsaeure;5-Hydroxymethyl-2-thiophenecarboxylic acid;5-hydroxymethyl-thiophene-2-carboxylic acid;

Chemical Property of 5-Hydroxymethyl-2-thiophene carbocylic acid

Chemical Property:

• PSA: 85.77000
• LogP: 0.93860

Purity/Quality:

98% ^*data from raw suppliers

5-Hydroxymethyl-2-thiophenecarboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Hydroxymethyl-2-thiophene carbocylic acid

There total 3 articles about 5-Hydroxymethyl-2-thiophene carbocylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-formyl-2-thiophencarboxylic acid (4565-31-5) → 5-(hydroxymethyl)thiophene-2-carboxylic acid (14282-64-5)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 8h; Inert atmosphere;

DOI:10.1016/j.bmc.2014.07.020

Reference yield: 89.0%

5-hydroxymethyl-2-thiophenecarboxylic acid methyl ester (530145-16-5) → 5-(hydroxymethyl)thiophene-2-carboxylic acid (14282-64-5)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃; for 1h;

Reference yield:

→ 5-(hydroxymethyl)thiophene-2-carboxylic acid (14282-64-5)

Guidance literature:

5-Acetoxymethyl-thiophen-carbonsaeure-(2)-methylester, sd. wss. NaOH;

upstream raw materials:

5-hydroxymethyl-2-thiophenecarboxylic acid methyl ester

5-formyl-2-thiophencarboxylic acid

Downstream raw materials:

2-thiophenylcarboxylic acid

Refernces

• 1、 Nagao, Satoshi,Yamane, Yoshinobu,Funasaka, Setsuo,Tanaka, Keigo,Miyazaki, Kazuki,Kotake, Yoshihiko,Kamata, Jun-Ichi,Watanabe-Miyano, Saori,Toyama, Osamu,Ozawa, Yoichi,Mizui, Yoshiharu,Okamoto, Kiyoshi,Ito, Daisuke. "Synthesis and structure-activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors". . p. 5513 - 5529. Retrieved 2014/12/10.
• 2、 -. "BENZENE OR THIOPHENE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR". Page/Page column 136-137. . Retrieved 2009/12/27.