4-[5-(2-amino-ethyl)-2,3-dimethoxy-phenoxy]-benzoic acid

Base Information

• Chemical Name: 4-[5-(2-amino-ethyl)-2,3-dimethoxy-phenoxy]-benzoic acid
• CAS No.: 101585-46-0
• Molecular Formula: C₁₇H₁₉NO₅
• Molecular Weight: 317.342
• Mol file: 101585-46-0.mol

Synonyms:

Chemical Property of 4-[5-(2-amino-ethyl)-2,3-dimethoxy-phenoxy]-benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[5-(2-amino-ethyl)-2,3-dimethoxy-phenoxy]-benzoic acid

There total 10 articles about 4-[5-(2-amino-ethyl)-2,3-dimethoxy-phenoxy]-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxy-4,5-dimethoxybenzaldehyde (29865-90-5) → 4-[5-(2-amino-ethyl)-2,3-dimethoxy-phenoxy]-benzoic acid (101585-46-0)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine

2: Reaktion ueber mehrere Stufen

3: KHCO₃; aqueous methanol

4: aqueous NaOH

5: platinum; acetic acid; H₂SO₄ / Hydrogenation

With pyridine; methanol; sodium hydroxide; sulfuric acid; potassium hydrogencarbonate; acetic acid; platinum;

Reference yield:

3,4-dimethoxy-5-methoxycarbonyloxy-benzoyl chloride → 4-[5-(2-amino-ethyl)-2,3-dimethoxy-phenoxy]-benzoic acid (101585-46-0)

Guidance literature:

Multi-step reaction with 7 steps

2: K₂CO₃; ethane-1,2-diol

3: pyridine

4: Reaktion ueber mehrere Stufen

5: KHCO₃; aqueous methanol

6: aqueous NaOH

7: platinum; acetic acid; H₂SO₄ / Hydrogenation

With pyridine; methanol; sodium hydroxide; sulfuric acid; potassium carbonate; potassium hydrogencarbonate; ethylene glycol; acetic acid; platinum;

Reference yield:

N-benzenesulfonyl-N'-(3,4-dimethoxy-5-methoxycarbonyloxy-benzoyl)-hydrazine (109566-96-3) → 4-[5-(2-amino-ethyl)-2,3-dimethoxy-phenoxy]-benzoic acid (101585-46-0)

Guidance literature:

Multi-step reaction with 6 steps

1: K₂CO₃; ethane-1,2-diol

2: pyridine

3: Reaktion ueber mehrere Stufen

4: KHCO₃; aqueous methanol

5: aqueous NaOH

6: platinum; acetic acid; H₂SO₄ / Hydrogenation

With pyridine; methanol; sodium hydroxide; sulfuric acid; potassium carbonate; potassium hydrogencarbonate; ethylene glycol; acetic acid; platinum;

upstream raw materials:

4-[2,3-dimethoxy-5-(2-nitro-vinyl)-phenoxy]-benzoic acid

methyl 3-nitro-4-chlorobenzoate

3-hydroxy-4,5-dimethoxybenzaldehyde

4-(5-formyl-2,3-dimethoxy-phenoxy)-benzoic acid methyl ester

Downstream raw materials:

4-[2,3-dimethoxy-5-(2-phthalimido-ethyl)-phenoxy]-benzoic acid