(2R)-2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]-N-(1-methylethyl)-2-{2-[(trifluoromethyl)oxy]phenyl}ethanamide

Base Information

Chemical Name:(2R)-2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]-N-(1-methylethyl)-2-{2-[(trifluoromethyl)oxy]phenyl}ethanamide
CAS No.:1354788-97-8
Molecular Formula:C₂₉H₃₄F₃N₃O₄
Molecular Weight:545.602
Hs Code.:

(2R)-2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]-N-(1-methylethyl)-2-{2-[(trifluoromethyl)oxy]phenyl}ethanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]-N-(1-methylethyl)-2-{2-[(trifluoromethyl)oxy]phenyl}ethanamide

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Technology Process of (2R)-2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]-N-(1-methylethyl)-2-{2-[(trifluoromethyl)oxy]phenyl}ethanamide

There total 2 articles about (2R)-2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]-N-(1-methylethyl)-2-{2-[(trifluoromethyl)oxy]phenyl}ethanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: C₃₅H₄₆F₃N₃O₇

: 1354788-97-8
(2R)-2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]-N-(1-methylethyl)-2-{2-[(trifluoromethyl)oxy]phenyl}ethanamide

Guidance literature:: In 1,4-dioxane; Acidic conditions;
DOI:10.1021/jm201287w

Reference yield:

: 181227-48-5,155172-73-9,181227-47-4
(2R)-[(t-butoxycarbonyl)amino](2,3-dihydro-1H-inden-2-yl)ethanoic acid

: 5845-53-4,6322-53-8,7517-19-3
(R)-leucine methyl ester hydrochloride

: 94651-33-9
2-(trifluoromethoxy)benzaldehyde

: 1354788-97-8
(2R)-2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2-methylpropyl)-2,5-dioxo-1-piperazinyl]-N-(1-methylethyl)-2-{2-[(trifluoromethyl)oxy]phenyl}ethanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / methanol

1.2: 20 °C

2.1: 1,4-dioxane / Acidic conditions

With triethylamine; In 1,4-dioxane; methanol; 1.1: Ugi condensation / 1.2: Ugi condensation;
DOI:10.1021/jm201287w