1-(4-Bromobenzyl)-2-butyl-4-chloro-1H-imidazole-5-carbaldehyde

Base Information

• Chemical Name: 1-(4-Bromobenzyl)-2-butyl-4-chloro-1H-imidazole-5-carbaldehyde
• CAS No.: 143722-29-6
• Molecular Formula: C15H16BrClN2O
• Molecular Weight: 355.662
• DSSTox Substance ID: DTXSID40433257
• Nikkaji Number: J1.641.220A
• Wikidata: Q82247382
• Mol file: 143722-29-6.mol

Synonyms:143722-29-6;1-(4-Bromobenzyl)-2-butyl-4-chloro-1H-imidazole-5-carbaldehyde;N-(4-Bromobenzyl)-2-butyl-4-chloro-1H-imidazole-5-carboxyaldehyde;3-[(4-bromophenyl)methyl]-2-butyl-5-chloroimidazole-4-carbaldehyde;2-n-butyl-4-chloro-1-(4-bromobenzyl)-5-formylimidazole;C15H16BrClN2O;SCHEMBL4639444;DTXSID40433257;MFCD18382199;1-[(4-Bromophenyl)methyl]-2-butyl-4-chloro-1H-imidazole-5-carboxaldehyde;1H-Imidazole-5-carboxaldehyde, 1-[(4-bromophenyl)methyl]-2-butyl-4-chloro-;CS-T-07926;DS-18983;CS-0061486;FT-0663643;W17279;A928681;J-007864;2-n-Butyl-4-chloro-1-p-bromobenzyl-1H-imidazole-5-carboxaldehyde;3-(4-bromobenzyl)-2-butyl-5-chloro-3h-imidazole-4-carboxaldehyde;3-[(4-Bromophenyl)methyl]-2-butyl-5-chloro-imidazole-4-carbaldehyde

Chemical Property of 1-(4-Bromobenzyl)-2-butyl-4-chloro-1H-imidazole-5-carbaldehyde

Chemical Property:

• PSA: 34.89000
• LogP: 4.50240
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 354.01345
• Heavy Atom Count: 20
• Complexity: 310

Purity/Quality:

97% ^*data from raw suppliers

N-(4-Bromobenzyl)-2-butyl-4-chloro-1H-imidazole-5-carboxyaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCC1=NC(=C(N1CC2=CC=C(C=C2)Br)C=O)Cl
• Uses: Intermediate in the production of Sartan derivatives

Technology Process of 1-(4-Bromobenzyl)-2-butyl-4-chloro-1H-imidazole-5-carbaldehyde

There total 5 articles about 1-(4-Bromobenzyl)-2-butyl-4-chloro-1H-imidazole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.9%

2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde (83857-96-9) + 1-bromomethyl-4-bromobenzene (589-15-1) → 3-(4-bromobenzyl)-2-butyl-5-chloro-3h-imidazole-4-carboxaldehyde (143722-29-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl acetamide; water; toluene;

Reference yield:

1-(4-bromo-benzyl)-2-butyl-1,5-dihydroimidazol-4-one + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 3-(4-bromobenzyl)-2-butyl-5-chloro-3h-imidazole-4-carboxaldehyde (143722-29-6)

Guidance literature:

1-(4-bromo-benzyl)-2-butyl-1,5-dihydroimidazol-4-one; N,N-dimethyl-formamide dimethyl acetal; In methanol; at 20 ℃; for 3h;

With trichlorophosphate; In toluene; at 0 - 100 ℃; for 2h; Product distribution / selectivity;

Reference yield:

1-(4-bromo-benzyl)-2-butyl-1,5-dihydroimidazol-4-one + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-(4-bromobenzyl)-2-butyl-5-chloro-3h-imidazole-4-carboxaldehyde (143722-29-6)

Guidance literature:

1-(4-bromo-benzyl)-2-butyl-1,5-dihydroimidazol-4-one; With trichlorophosphate; In toluene; at 0 - 90 ℃;

N,N-dimethyl-formamide; In toluene; at 115 ℃; for 2h; Product distribution / selectivity;

upstream raw materials:

2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde

1-bromomethyl-4-bromobenzene

N,N-dimethyl-formamide dimethyl acetal

N,N-dimethyl-formamide

Downstream raw materials:

2-n-Butyl-4-chloro-1-(4-bromobenzyl)-1H-imidazole-5-methanol

2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol