2-(Dichloromethyl)imidazo[1,2-a]pyridine

Base Information

• Chemical Name: 2-(Dichloromethyl)imidazo[1,2-a]pyridine
• CAS No.: 143982-35-8
• Molecular Formula: C8H6Cl2N2
• Molecular Weight: 201.05300
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID90465063
• Nikkaji Number: J1.929.638E
• Wikidata: Q82290733
• Mol file: 143982-35-8.mol

Synonyms:2-(Dichloromethyl)imidazo[1,2-a]pyridine;143982-35-8;SCHEMBL21045066;DTXSID90465063;3-(4-Acetylaminobenzoyl)propanoicacid;AKOS015995100;G11936

Chemical Property of 2-(Dichloromethyl)imidazo[1,2-a]pyridine

Chemical Property:

• PSA: 17.30000
• LogP: 2.81050
• Storage Temp.: 2-8°C
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 199.9908036
• Heavy Atom Count: 12
• Complexity: 163

Purity/Quality:

98%min ^*data from raw suppliers

2-dichloromethyl-imidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC(=CN2C=C1)C(Cl)Cl

Technology Process of 2-(Dichloromethyl)imidazo[1,2-a]pyridine

There total 2 articles about 2-(Dichloromethyl)imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-aminopyridine (504-29-0) + 1,1,3-trichloroacetone (921-03-9) → imidazo[1,2-a]pyridine-2-carbaldehyde (118000-43-4) + 2-dichloromethylimidazo<1,2-a>pyridine (143982-35-8) + 2-diethoxymethylimidazo[1,2-a]pyridine (143982-36-9)

Guidance literature:

In 1,2-dimethoxyethane; for 4h; Ambient temperature;

DOI:10.1002/jhet.5570290403

Reference yield: 71.0%

2-aminopyridine (504-29-0) + 1,1,3-trichloroacetone (921-03-9) → 2-dichloromethylimidazo<1,2-a>pyridine (143982-35-8)

Guidance literature:

2-aminopyridine; 1,1,3-trichloroacetone; In 1,2-dimethoxyethane; at 20 ℃; for 4h;

In ethanol; for 12h; Heating;

DOI:10.3987/com-01-9347

Reference yield:

2-dichloromethylimidazo<1,2-a>pyridine (143982-35-8) → N-(2-(cyclohexylamino)-1-(imidazo[1,2-a]pyridin-2-yl)-2-oxoethyl)-N-(4-methoxybenzyl)propiolamide

Guidance literature:

Multi-step reaction with 2 steps

1: calcium carbonate / water / 1 h / Reflux

2: sodium carbonate / methanol / 20 °C

With sodium carbonate; calcium carbonate; In methanol; water; 2: |Ugi Condensation;

DOI:10.1002/ejoc.201500270

upstream raw materials:

2-aminopyridine

1,1,3-trichloroacetone

Downstream raw materials:

imidazo[1,2-a]pyridine-2-carbaldehyde

3-bromoimidazo<1,2-a>pyridine-2-carboxaldehyde

3-nitroimidazo[1,2-a]pyridine-2-carbaldehyde

ethyl 3-imidazo[1,2-a]pyridine-2-carboxylate