Naphtho[2,3-c]furan-1(3H)-one, 6,7-dimethoxy-9-(4-methoxyphenyl)-

Base Information

• Chemical Name: Naphtho[2,3-c]furan-1(3H)-one, 6,7-dimethoxy-9-(4-methoxyphenyl)-
• CAS No.: 145726-16-5
• Molecular Formula: C21H18O5
• Molecular Weight: 350.371
• Mol file: 145726-16-5.mol

Synonyms:

Chemical Property of Naphtho[2,3-c]furan-1(3H)-one, 6,7-dimethoxy-9-(4-methoxyphenyl)-

Chemical Property:

• Boiling Point: 575.8±50.0 °C(Predicted)
• PSA: 53.99000
• Density: 1.262±0.06 g/cm3(Predicted)
• LogP: 4.20300

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Naphtho[2,3-c]furan-1(3H)-one, 6,7-dimethoxy-9-(4-methoxyphenyl)-

There total 14 articles about Naphtho[2,3-c]furan-1(3H)-one, 6,7-dimethoxy-9-(4-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

6,7-dimethoxy-3-oxo-1,3-dihydronaphtho[2,3-c]furan-4-yl trifluoromethanesulfonate + potassium 4-(methoxy)phenyltrifluoroborate → 6,7-dimethoxy-9-(4-methoxyphenyl)naphtho[2,3-c]furan-1(3H)-one (145726-16-5)

Guidance literature:

With palladium diacetate; potassium carbonate; tricyclohexylphosphine; In 1,4-dioxane; water; for 17h; Heating;

DOI:10.1080/14786419.2021.1948843

Reference yield:

C21H20O4 (1276122-32-7) → 6,7-dimethoxy-9-(4-methoxyphenyl)naphtho[2,3-c]furan-1(3H)-one (145726-16-5) + 6,7-Dimethoxy-4-(4-methoxy-phenyl)-3H-naphtho[2,3-c]furan-1-one

Guidance literature:

With potassium permanganate; copper(ll) sulfate pentahydrate; In dichloromethane; for 72h; Reflux;

DOI:10.1016/j.tetlet.2011.01.011

Reference yield:

C21H22O5 → 6,7-dimethoxy-9-(4-methoxyphenyl)naphtho[2,3-c]furan-1(3H)-one (145726-16-5) + 6,7-Dimethoxy-4-(4-methoxy-phenyl)-3H-naphtho[2,3-c]furan-1-one

Guidance literature:

With Fetizon’s reagent; In benzene; Dean-Stark; Reflux;

DOI:10.2174/1573406416666200610190417

upstream raw materials:

C₂₁H₂₀O₄

2-bromo-4,5-dimethoxybenzaldehyde

Veratric acid

2-(2-bromo-4,5-dimethoxyphenyl)-1,3-dioxolane

Refernces

• 1、 Chen, Wang,Feng, Zili,Hu, Daihua,Meng, Jin. "Design and synthesis of arylnaphthalene lignan lactone derivatives as potent topoisomerase inhibitors". . p. 856 - 865. Retrieved 2021/10/21.