alpha-(3-Phenylpropyl)-3-pyridinebutanol

Base Information

Chemical Name:alpha-(3-Phenylpropyl)-3-pyridinebutanol
CAS No.:145912-94-3
Molecular Formula:C18H23NO
Molecular Weight:269.387
Hs Code.:
DSSTox Substance ID:DTXSID801290139
Mol file:145912-94-3.mol

Synonyms:SCHEMBL7384270;DTXSID801290139;alpha-(3-Phenylpropyl)-3-pyridinebutanol;145912-94-3

Suppliers and Price of alpha-(3-Phenylpropyl)-3-pyridinebutanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of alpha-(3-Phenylpropyl)-3-pyridinebutanol

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:8
Exact Mass:269.177964357
Heavy Atom Count:20
Complexity:238

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)CCCC(CCCC2=CN=CC=C2)O

Technology Process of alpha-(3-Phenylpropyl)-3-pyridinebutanol

There total 3 articles about alpha-(3-Phenylpropyl)-3-pyridinebutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 637-59-2
1-Bromo-3-phenylpropane

: 145912-93-2
4-(3-pyridinyl)butyraldehyde

: 145912-94-3
1-phenyl-7-(3-pyridyl)heptan-4-ol

Guidance literature:: 1-Bromo-3-phenylpropane; With magnesium; 1,1-Dibromoethane; In tetrahydrofuran; for 1h; cooling;

4-(3-pyridinyl)butyraldehyde; In tetrahydrofuran; at 20 ℃; for 1h; Further stages.;
DOI:10.1021/ol0166909

Reference yield:

: 60753-14-2
3-(4-hydroxybutyl)-pyridine

: 145912-94-3
1-phenyl-7-(3-pyridyl)heptan-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 73 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

2.1: Mg / dibromoethane / tetrahydrofuran / 1 h / cooling

2.2: 68 percent / tetrahydrofuran / 1 h / 20 °C

With oxalyl dichloride; magnesium; dimethyl sulfoxide; triethylamine; 1,1-Dibromoethane; In tetrahydrofuran; dichloromethane; 1.1: Swern oxidation;
DOI:10.1021/ol0166909

Reference yield:

: 174523-91-2
4-(3-pyridyl)butyl tert-butyldimethylsilyl ether

: 145912-94-3
1-phenyl-7-(3-pyridyl)heptan-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 81 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2.1: 73 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

3.1: Mg / dibromoethane / tetrahydrofuran / 1 h / cooling

3.2: 68 percent / tetrahydrofuran / 1 h / 20 °C

With oxalyl dichloride; tetrabutyl ammonium fluoride; magnesium; dimethyl sulfoxide; triethylamine; 1,1-Dibromoethane; In tetrahydrofuran; dichloromethane; 2.1: Swern oxidation;
DOI:10.1021/ol0166909