Tert-butyl 3-(2-iodoethyl)piperidine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 3-(2-iodoethyl)piperidine-1-carboxylate
CAS No.:146667-86-9
Molecular Formula:C₁₂H₂₂INO₂
Molecular Weight:339.217
Hs Code.:2933399090
DSSTox Substance ID:DTXSID10435480
Mol file:146667-86-9.mol

Synonyms:Tert-butyl 3-(2-iodoethyl)piperidine-1-carboxylate;146667-86-9;1-Boc-3-(2-Iodoethyl)piperidine;SCHEMBL7256012;DTXSID10435480;WFA66786;AKOS024463128;AB91475;AM100255;CS-0079190;FT-0765720;D74044;A884491;Tert-butyl3-(2-iodoethyl)piperidine-1-carboxylate

Suppliers and Price of Tert-butyl 3-(2-iodoethyl)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl3-(2-iodoethyl)piperidine-1-carboxylate 95+%
1g
$ 715.00

Chemenu
tert-Butyl3-(2-iodoethyl)piperidine-1-carboxylate 95%
1g
$ 669.00

Alichem
tert-Butyl3-(2-iodoethyl)piperidine-1-carboxylate
1g
$ 576.00

Acrotein
1-Boc-3-(2-iodoethyl)piperidine 97%
1g
$ 366.67

ACHEMBLOCK
1-Boc-3-(2-iodoethyl)piperidine 95%
250MG
$ 200.00

Total 9 raw suppliers

Chemical Property of Tert-butyl 3-(2-iodoethyl)piperidine-1-carboxylate

Chemical Property:

Boiling Point:351.9±15.0 °C(Predicted)
PKA:-1.52±0.40(Predicted)
PSA：29.54000
Density:1.406±0.06 g/cm3(Predicted)
LogP:3.39650
XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:339.06953
Heavy Atom Count:16
Complexity:238

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3-(2-iodoethyl)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCCC(C1)CCI

Technology Process of Tert-butyl 3-(2-iodoethyl)piperidine-1-carboxylate

There total 1 articles about Tert-butyl 3-(2-iodoethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 146667-84-7
tert-butyl 3-(2-hydroxyethyl)-1-piperidinecarboxylate

: 146667-86-9
3-(2-iodo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:

Reference yield:

: 146667-86-9
3-(2-iodo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

: BMS-354326

Guidance literature:: Multi-step reaction with 6 steps

1: LDA / tetrahydrofuran

2: TBAF / tetrahydrofuran

3: NaHCO₃

4: TEA; DMAP / dimethylformamide

5: TFA / CH₂Cl₂

6: H₂ / Pd/C / dioxane

With dmap; TEA; tetrabutyl ammonium fluoride; hydrogen; sodium hydrogencarbonate; trifluoroacetic acid; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.02.011

Reference yield:

: 146667-86-9
3-(2-iodo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

: 705951-18-4
3-[2-((2S,3R)-2-Benzyloxycarbonyl-4-oxo-azetidin-3-yl)-ethyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: LDA / tetrahydrofuran

2: TBAF / tetrahydrofuran

3: NaHCO₃

With tetrabutyl ammonium fluoride; sodium hydrogencarbonate; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2004.02.011