L-Cysteine, S-[[2-carboxy-4,6-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methylphen yl]methyl]-N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, 1-methyl ester

Base Information

Chemical Name:L-Cysteine, S-[[2-carboxy-4,6-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methylphen yl]methyl]-N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, 1-methyl ester
CAS No.:147214-64-0
Molecular Formula:C33H58N2O10SSi2
Molecular Weight:731.068
Hs Code.:

L-Cysteine,
S-[[2-carboxy-4,6-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methylphen
yl]methyl]-N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, 1-methyl ester

Synonyms:

Suppliers and Price of L-Cysteine, S-[[2-carboxy-4,6-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methylphen yl]methyl]-N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, 1-methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of L-Cysteine, S-[[2-carboxy-4,6-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methylphen yl]methyl]-N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, 1-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Cysteine, S-[[2-carboxy-4,6-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methylphen yl]methyl]-N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, 1-methyl ester

There total 11 articles about L-Cysteine, S-[[2-carboxy-4,6-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methylphen yl]methyl]-N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 186132-88-7
2-[(R)-2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionylamino)-2-methoxycarbonyl-ethylsulfanylmethyl]-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-benzoic acid 4-nitro-benzyl ester

: 147214-64-0
2-[(R)-2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionylamino)-2-methoxycarbonyl-ethylsulfanylmethyl]-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-benzoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 15h; Ambient temperature;
DOI:10.1002/hlca.19960790816

Reference yield:

: 99-10-5
3,5-Dihydroxybenzoic acid

: 147214-64-0
2-[(R)-2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionylamino)-2-methoxycarbonyl-ethylsulfanylmethyl]-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-benzoic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 92 percent / H₂O; ethanol / 15 h / Ambient temperature; pH 5

2: 88 percent / H₂, piperidine / 5percent Pd/C / methanol; H₂O / 14 h / 75.01 Torr

3: 58 percent / H₂O; ethanol / 15 h / Ambient temperature; pH 5

4: 70 percent / H₂, 3N NaOH / 5percent Pd/C / methanol; H₂O / 14 h / 75.01 Torr

5: 82 percent / N,N,N',N'-tetramethylguanidine / dimethylformamide / 6 h / Ambient temperature

6: 91 percent / Et₃N / dimethylformamide / 1.5 h / 0 °C

7: 67 percent / N-bromosuccinimide / CCl₄ / 0.83 h / Heating; Irradiation

8: 54 percent / Et₃N / CH₂Cl₂ / 0 deg C, 1 h; room temp., 2 h

9: 93 percent / H₂ / 5percent Pd/C / ethyl acetate / 15 h / Ambient temperature

With piperidine; sodium hydroxide; N-Bromosuccinimide; hydrogen; triethylamine; N,N,N',N'-tetramethylguanidine; palladium on activated charcoal; In methanol; tetrachloromethane; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19960790816

Reference yield:

: 3262-72-4
(S)-N-(tert-butoxycarbonyl)serine

: 147214-64-0
2-[(R)-2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionylamino)-2-methoxycarbonyl-ethylsulfanylmethyl]-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / N-methylmorpholine, N,N'-dicyclohexylcarbodiimide / acetonitrile / 4.5 h / 5 °C

2: 54 percent / Et₃N / CH₂Cl₂ / 0 deg C, 1 h; room temp., 2 h

3: 93 percent / H₂ / 5percent Pd/C / ethyl acetate / 15 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1002/hlca.19960790816