Technology Process of Carbamic acid,
[1,2-dihydro-2-oxo-6-phenyl-1-[2-oxo-2-[[3,3,3-trifluoro-1-(1-methylethyl)
-2-oxopropyl]amino]ethyl]-3-pyridinyl]-, phenylmethyl ester
There total 23 articles about Carbamic acid,
[1,2-dihydro-2-oxo-6-phenyl-1-[2-oxo-2-[[3,3,3-trifluoro-1-(1-methylethyl)
-2-oxopropyl]amino]ethyl]-3-pyridinyl]-, phenylmethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dichloro-acetic acid;
In
dimethyl sulfoxide; toluene;
DOI:10.1021/jm00046a016
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 4-methyl-morpholine / tetrahydrofuran / 12 h
2: 2,6-dimethylpyridine / dichloromethane / 12 h
3: sodium iodide / acetone / 12 h / Ambient temperature
4: sodium hydride / 1.) DMF, RT, 15 min, 2.) DMF, RT, 12 h
5: tetrabutyl ammonium fluoride / tetrahydrofuran / 4.5 h
6: dichloro-acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dimethyl sulfoxide; toluene / 12 h
With
4-methyl-morpholine; 2,6-dimethylpyridine; dichloro-acetic acid; tetrabutyl ammonium fluoride; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium iodide;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetone; toluene;
DOI:10.1021/jm00046a015
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium iodide / acetone / 12 h / Ambient temperature
2: sodium hydride / 1.) DMF, RT, 15 min, 2.) DMF, RT, 12 h
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 4.5 h
4: dichloro-acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dimethyl sulfoxide; toluene / 12 h
With
dichloro-acetic acid; tetrabutyl ammonium fluoride; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium iodide;
In
tetrahydrofuran; dimethyl sulfoxide; acetone; toluene;
DOI:10.1021/jm00046a015
