Carbamic acid, [1,2-dihydro-2-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-hydroxy-1-(1-methylethyl )propyl]amino]ethyl]-6-phenyl-3-pyridinyl]-, phenylmethyl ester

Base Information

• Chemical Name: Carbamic acid, [1,2-dihydro-2-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-hydroxy-1-(1-methylethyl )propyl]amino]ethyl]-6-phenyl-3-pyridinyl]-, phenylmethyl ester
• CAS No.: 147269-03-2
• Molecular Formula: C27H28F3N3O5
• Molecular Weight: 531.532
• Mol file: 147269-03-2.mol

Synonyms:

Chemical Property of Carbamic acid, [1,2-dihydro-2-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-hydroxy-1-(1-methylethyl )propyl]amino]ethyl]-6-phenyl-3-pyridinyl]-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [1,2-dihydro-2-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-hydroxy-1-(1-methylethyl )propyl]amino]ethyl]-6-phenyl-3-pyridinyl]-, phenylmethyl ester

There total 22 articles about Carbamic acid, [1,2-dihydro-2-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-hydroxy-1-(1-methylethyl )propyl]amino]ethyl]-6-phenyl-3-pyridinyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide (147269-02-1) → 2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide (147269-03-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 4.5h;

DOI:10.1021/jm00046a016

Reference yield: 67.0%

2-(3-(((benzyloxy)carbonyl)amino)-2-oxo-6-phenylpyridin-1(2H)-yl)acetic acid + 3(RS)-amino-1,1,1-trifluoro-2(RS)-hydroxy-4-methylpentane hydrochloride (106746-09-2) → 2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide (147269-03-2)

Guidance literature:

With 4-methyl-morpholine; dmap; 1-hydroxy-1H-benzotriazole hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃; for 72h; Inert atmosphere;

DOI:10.1039/d1cc03624f

Reference yield:

3(RS)-amino-1,1,1-trifluoro-2(RS)-hydroxy-4-methylpentane hydrochloride (106746-09-2) → 2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide (147269-03-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 4-methyl-morpholine / tetrahydrofuran / 12 h

2: 2,6-dimethylpyridine / dichloromethane / 12 h

3: sodium iodide / acetone / 12 h / Ambient temperature

4: sodium hydride / 1.) DMF, RT, 15 min, 2.) DMF, RT, 12 h

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 4.5 h

With 4-methyl-morpholine; 2,6-dimethylpyridine; tetrabutyl ammonium fluoride; sodium hydride; sodium iodide; In tetrahydrofuran; dichloromethane; acetone;

DOI:10.1021/jm00046a015

upstream raw materials:

2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide

3(RS)-amino-1,1,1-trifluoro-2(RS)-hydroxy-4-methylpentane hydrochloride

1,2-dihydro-2-oxo-6-phenylpyridine-3-carbonitrile

2-oxo-6-phenyl-1,2-dihydropyridine-3-carboxylic acid