Carbamic acid, [1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-6-(4-methoxyphenyl)-2-oxo- 3-pyridinyl]-, phenylmethyl ester

Base Information

Chemical Name:Carbamic acid, [1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-6-(4-methoxyphenyl)-2-oxo- 3-pyridinyl]-, phenylmethyl ester
CAS No.:147269-09-8
Molecular Formula:C₃₄H₄₄F₃N₃O₆Si
Molecular Weight:675.821
Hs Code.:
Mol file:147269-09-8.mol

Carbamic acid,
[1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl
ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-6-(4-methoxyphenyl)-2-oxo-
3-pyridinyl]-, phenylmethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-6-(4-methoxyphenyl)-2-oxo- 3-pyridinyl]-, phenylmethyl ester

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Technology Process of Carbamic acid, [1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-6-(4-methoxyphenyl)-2-oxo- 3-pyridinyl]-, phenylmethyl ester

There total 13 articles about Carbamic acid, [1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-6-(4-methoxyphenyl)-2-oxo- 3-pyridinyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147269-04-3
2-chloro-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

: 147269-09-8
2-[3-benzyloxycarbonylamino-6-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

: [2-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methoxy}-6-(4-methoxy-phenyl)-pyridin-3-yl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-dimethylpyridine / dichloromethane / 12 h

2: sodium iodide / acetone / 12 h / Ambient temperature

3: sodium hydride / 1.) DMF, RT, 2.) DMF, RT

With 2,6-dimethylpyridine; sodium hydride; sodium iodide; In dichloromethane; acetone;
DOI:10.1021/jm00046a015

Reference yield:

: 147283-20-3
N-(2-tert-Butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropyl-propyl)-2-chloroacetamide

: 147269-09-8
2-[3-benzyloxycarbonylamino-6-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

: [2-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methoxy}-6-(4-methoxy-phenyl)-pyridin-3-yl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium iodide / acetone / 12 h / Ambient temperature

2: sodium hydride / 1.) DMF, RT, 2.) DMF, RT

With sodium hydride; sodium iodide; In acetone;
DOI:10.1021/jm00046a015

Reference yield:

: 56162-63-1
2-oxo-6-phenyl-1,2-dihydropyridine-3-carboxylic acid

: 147269-09-8
2-[3-benzyloxycarbonylamino-6-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

: [2-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methoxy}-6-(4-methoxy-phenyl)-pyridin-3-yl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diphenyl-phosphinic acid; triethylamine / 1,4-dioxane / 4 h / Heating

2: 1,4-dioxane / 12 h / Heating

3: sodium hydride / 1.) DMF, RT, 2.) DMF, RT

With diphenyl-phosphinic acid; sodium hydride; triethylamine; In 1,4-dioxane;
DOI:10.1021/jm00046a015