6-(4-methylphenyl)-2-oxo-1H-pyridine-3-carboxylic Acid

Base Information

• Chemical Name: 6-(4-methylphenyl)-2-oxo-1H-pyridine-3-carboxylic Acid
• CAS No.: 147269-18-9
• Molecular Formula: C₁₃H₁₁NO₃
• Molecular Weight: 229.235
• European Community (EC) Number: 888-850-6
• Mol file: 147269-18-9.mol

Synonyms:147269-18-9;6-(4-methylphenyl)-2-oxo-1H-pyridine-3-carboxylic Acid;6-(4-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid;2-Oxo-6-(p-tolyl)-1,2-dihydropyridine-3-carboxylic acid;SCHEMBL11319316;SCHEMBL25149281;MFCD11656483;2-Hydroxy-6-(p-tolyl)nicotinic acid;AKOS010924091;NS-02936;BB 0219277;CS-0281291;EN300-238982;F2130-0162

Chemical Property of 6-(4-methylphenyl)-2-oxo-1H-pyridine-3-carboxylic Acid

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 229.07389321
• Heavy Atom Count: 17
• Complexity: 401

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=CC=C(C(=O)N2)C(=O)O

Technology Process of 6-(4-methylphenyl)-2-oxo-1H-pyridine-3-carboxylic Acid

There total 3 articles about 6-(4-methylphenyl)-2-oxo-1H-pyridine-3-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-oxo-6-p-tolyl-1,2-dihydro-pyridine-3-carbonitrile (37670-85-2) → 2-Oxo-6-p-tolyl-1,2-dihydro-pyridine-3-carboxylic acid (147269-18-9)

Guidance literature:

With sodium hydroxide; at 140 ℃;

DOI:10.1021/jm00046a015

Reference yield:

para-methylacetophenone (122-00-9) → 2-Oxo-6-p-tolyl-1,2-dihydro-pyridine-3-carboxylic acid (147269-18-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium methylate; acetic acid / 1.) THF, ether, 40 deg C, 2.) water, 90 deg C

2: sodium hydroxide / 140 °C

With sodium hydroxide; sodium methylate; acetic acid;

DOI:10.1021/jm00046a015

Reference yield:

2-hydroxy-6-p-tolyl-nicotinonitrile (37670-85-2) → 2-hydroxy-6-p-tolyl-nicotinic acid (147269-18-9)

Guidance literature:

With sulfuric acid;

upstream raw materials:

2-hydroxy-6-p-tolyl-nicotinonitrile

2-oxo-6-p-tolyl-1,2-dihydro-pyridine-3-carbonitrile

para-methylacetophenone

Downstream raw materials:

(1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-6-p-tolyl-1,2-dihydro-pyridin-3-yl)-carbamic acid benzyl ester

{2-Oxo-6-p-tolyl-1-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-carbamic acid benzyl ester

(2-Oxo-6-p-tolyl-1,2-dihydro-pyridin-3-yl)-carbamic acid benzyl ester

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