Carbamic acid, [1,2-dihydro-2-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-hydroxy-1-(1-methylethyl )propyl]amino]ethyl]-6-phenyl-3-pyridinyl]-, 4-pyridinylmethyl ester

Base Information

Chemical Name:Carbamic acid, [1,2-dihydro-2-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-hydroxy-1-(1-methylethyl )propyl]amino]ethyl]-6-phenyl-3-pyridinyl]-, 4-pyridinylmethyl ester
CAS No.:147283-50-9
Molecular Formula:C26H27F3N4O5
Molecular Weight:532.519
Hs Code.:
Mol file:147283-50-9.mol

Carbamic acid,
[1,2-dihydro-2-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-hydroxy-1-(1-methylethyl
)propyl]amino]ethyl]-6-phenyl-3-pyridinyl]-, 4-pyridinylmethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [1,2-dihydro-2-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-hydroxy-1-(1-methylethyl )propyl]amino]ethyl]-6-phenyl-3-pyridinyl]-, 4-pyridinylmethyl ester

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Technology Process of Carbamic acid, [1,2-dihydro-2-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-hydroxy-1-(1-methylethyl )propyl]amino]ethyl]-6-phenyl-3-pyridinyl]-, 4-pyridinylmethyl ester

There total 5 articles about Carbamic acid, [1,2-dihydro-2-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-hydroxy-1-(1-methylethyl )propyl]amino]ethyl]-6-phenyl-3-pyridinyl]-, 4-pyridinylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147269-02-1
2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide

: 147283-50-9
2-<2-oxo-6-phenyl-3-<<(4-pyridylmethoxy)carbonyl>amino>-1,2-dihydro-1-pyridyl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 5 h / 760 Torr

2: Et₃N / CH₂Cl₂ / 0.75 h / 0 °C

3: CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) RT, overnight

4: tetrabutylammonium fluoride / tetrahydrofuran / 4.5 h

With tetrabutyl ammonium fluoride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00046a016

Reference yield:

: 147283-49-6
N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>-2-<2-oxo-6-phenyl-3-<<(4-pyridylmethoxy)carbonyl>amino>-1,2-dihydro-1-pyridyl>acetamide

: 147283-50-9
2-<2-oxo-6-phenyl-3-<<(4-pyridylmethoxy)carbonyl>amino>-1,2-dihydro-1-pyridyl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 4.5h;
DOI:10.1021/jm00046a016

Reference yield:

: 586-95-8
pyridine-4-methanol

: 147283-50-9
2-<2-oxo-6-phenyl-3-<<(4-pyridylmethoxy)carbonyl>amino>-1,2-dihydro-1-pyridyl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) RT, overnight

2: tetrabutylammonium fluoride / tetrahydrofuran / 4.5 h

With tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00046a016