Carbamic acid, [6-(3,5-dimethoxyphenyl)-1,2-dihydro-2-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2 -hydroxy-1-(1-methylethyl)propyl]amino]ethyl]-3-pyridinyl]-, phenylmethyl ester

Base Information

Chemical Name:Carbamic acid, [6-(3,5-dimethoxyphenyl)-1,2-dihydro-2-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2 -hydroxy-1-(1-methylethyl)propyl]amino]ethyl]-3-pyridinyl]-, phenylmethyl ester
CAS No.:147313-45-9
Molecular Formula:C₂₉H₃₂F₃N₃O₇
Molecular Weight:591.584
Hs Code.:
Mol file:147313-45-9.mol

Carbamic acid,
[6-(3,5-dimethoxyphenyl)-1,2-dihydro-2-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2
-hydroxy-1-(1-methylethyl)propyl]amino]ethyl]-3-pyridinyl]-, phenylmethyl
ester

Synonyms:

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Chemical Property of Carbamic acid, [6-(3,5-dimethoxyphenyl)-1,2-dihydro-2-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2 -hydroxy-1-(1-methylethyl)propyl]amino]ethyl]-3-pyridinyl]-, phenylmethyl ester

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Technology Process of Carbamic acid, [6-(3,5-dimethoxyphenyl)-1,2-dihydro-2-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2 -hydroxy-1-(1-methylethyl)propyl]amino]ethyl]-3-pyridinyl]-, phenylmethyl ester

There total 10 articles about Carbamic acid, [6-(3,5-dimethoxyphenyl)-1,2-dihydro-2-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2 -hydroxy-1-(1-methylethyl)propyl]amino]ethyl]-3-pyridinyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147313-43-7
[1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-6-(3,5-dimethoxy-phenyl)-2-oxo-1,2-dihydro-pyridin-3-yl]-carbamic acid benzyl ester

: 147313-45-9
{6-(3,5-Dimethoxy-phenyl)-2-oxo-1-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-carbamic acid benzyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1021/jm00046a015

Reference yield:

: 39151-19-4
1-(3,5-dimethoxyphenyl)ethan-1-one

: 147313-45-9
{6-(3,5-Dimethoxy-phenyl)-2-oxo-1-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: sodium methylate; acetic acid / 1.) THF, ether, 40 deg C, 2.) water, 90 deg C

2: sodium hydroxide / 140 °C

3: diphenyl-phosphinic acid; triethylamine / 1,4-dioxane / Heating

4: 1,4-dioxane / Heating

5: sodium hydride / 1.) DMF, RT, 2.) DMF, RT

6: tetrabutyl ammonium fluoride / tetrahydrofuran

With sodium hydroxide; diphenyl-phosphinic acid; tetrabutyl ammonium fluoride; sodium methylate; sodium hydride; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm00046a015

Reference yield:

: 106746-09-2
3(RS)-amino-1,1,1-trifluoro-2(RS)-hydroxy-4-methylpentane hydrochloride

: 147313-45-9
{6-(3,5-Dimethoxy-phenyl)-2-oxo-1-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 4-methyl-morpholine / tetrahydrofuran / 12 h

2: 2,6-dimethylpyridine / dichloromethane / 12 h

3: sodium iodide / acetone / 12 h / Ambient temperature

4: sodium hydride / 1.) DMF, RT, 2.) DMF, RT

5: tetrabutyl ammonium fluoride / tetrahydrofuran

With 4-methyl-morpholine; 2,6-dimethylpyridine; tetrabutyl ammonium fluoride; sodium hydride; sodium iodide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/jm00046a015