N-(3-chloro-4-methylphenyl)-N-(4-chlorophenyl)sulfonylacetamide

Base Information

• Chemical Name: N-(3-chloro-4-methylphenyl)-N-(4-chlorophenyl)sulfonylacetamide
• CAS No.: 5614-44-8
• Molecular Formula: C₁₀H₁₂N₄O₃
• Molecular Weight: 236.23
• DSSTox Substance ID: DTXSID30359679
• Wikidata: Q82140974
• Mol file: 5614-44-8.mol

Synonyms:5614-44-8;DTXSID30359679;N-(3-chloro-4-methylphenyl)-N-(4-chlorophenyl)sulfonylacetamide;AKOS001085737;Z57043567;N-(3-chloro-4-methylphenyl)-N-[(4-chlorophenyl)sulfonyl]acetamide

Chemical Property of N-(3-chloro-4-methylphenyl)-N-(4-chlorophenyl)sulfonylacetamide

Chemical Property:

• Vapor Pressure: 1.89E-10mmHg at 25°C
• Boiling Point: 508.2°C at 760 mmHg
• Flash Point: 261.2°C
• Density: 1.427g/cm³
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 356.9993198
• Heavy Atom Count: 22
• Complexity: 497

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=C(C=C1)N(C(=O)C)S(=O)(=O)C2=CC=C(C=C2)Cl)Cl

Technology Process of N-(3-chloro-4-methylphenyl)-N-(4-chlorophenyl)sulfonylacetamide

There total 6 articles about N-(3-chloro-4-methylphenyl)-N-(4-chlorophenyl)sulfonylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H16N4O5 → (2R,3R,5S)-5-(hydroxymethyl)-2-(9H-purin-9-yl)tetrahydrofuran-3-ol (3608-62-6,5614-44-8)

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 1h;

DOI:10.1021/jm401530a

Reference yield:

cordycepin (73-03-0) → (2R,3R,5S)-5-(hydroxymethyl)-2-(9H-purin-9-yl)tetrahydrofuran-3-ol (3608-62-6,5614-44-8)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 0.5 h / 20 °C

2: tert.-butylnitrite / tetrahydrofuran / 0.5 h / 60 °C

3: ammonia / methanol / 1 h / 20 °C

With pyridine; tert.-butylnitrite; ammonia; In tetrahydrofuran; methanol;

DOI:10.1021/jm401530a

Reference yield:

((2S,4R,5R)-4-acetoxy-5-(6-amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl acetate (71196-28-6) → (2R,3R,5S)-5-(hydroxymethyl)-2-(9H-purin-9-yl)tetrahydrofuran-3-ol (3608-62-6,5614-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tert.-butylnitrite / tetrahydrofuran / 0.5 h / 60 °C

2: ammonia / methanol / 1 h / 20 °C

With tert.-butylnitrite; ammonia; In tetrahydrofuran; methanol;

DOI:10.1021/jm401530a

upstream raw materials:

cordycepin

((2S,4R,5R)-4-acetoxy-5-(6-amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl acetate

adenosine

9-(2,3-anhydro-β-D-ribofuranosyl)adenine