Benzamide, N-[[4'-[[3-butyl-1,5-dihydro-1-(3-nitrophenyl)-5-oxo-4H-1,2,4-triazol-4-yl] methyl][1,1'-biphenyl]-2-yl]sulfonyl]-2-chloro-

Base Information

Chemical Name:Benzamide, N-[[4'-[[3-butyl-1,5-dihydro-1-(3-nitrophenyl)-5-oxo-4H-1,2,4-triazol-4-yl] methyl][1,1'-biphenyl]-2-yl]sulfonyl]-2-chloro-
CAS No.:147776-55-4
Molecular Formula:C32H28ClN5O6S
Molecular Weight:646.123
Hs Code.:
Mol file:147776-55-4.mol

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Chemical Property of Benzamide, N-[[4'-[[3-butyl-1,5-dihydro-1-(3-nitrophenyl)-5-oxo-4H-1,2,4-triazol-4-yl] methyl][1,1'-biphenyl]-2-yl]sulfonyl]-2-chloro-

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Technology Process of Benzamide, N-[[4'-[[3-butyl-1,5-dihydro-1-(3-nitrophenyl)-5-oxo-4H-1,2,4-triazol-4-yl] methyl][1,1'-biphenyl]-2-yl]sulfonyl]-2-chloro-

There total 8 articles about Benzamide, N-[[4'-[[3-butyl-1,5-dihydro-1-(3-nitrophenyl)-5-oxo-4H-1,2,4-triazol-4-yl] methyl][1,1'-biphenyl]-2-yl]sulfonyl]-2-chloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 67333-74-8
1-(2-chloro-benzoyl)-1H-imidazole

: 147776-54-3
5-n-butyl-2,4-dihydro-2-(3-nitrophenyl)-4-[(2'-sulfamoylbiphenyl-4-yl)methyl]-3H-1,2,4-triazol-3-one

: 147776-55-4
5-n-butyl-4-[[2'-[N-(2-chlorobenzoyl)sulfamoyl]biphenyl-4-yl]methyl]-2,4-dihydro-2-(3-nitrophenyl)-3H-1,2,4-triazol-3-one

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 50 ℃;
DOI:10.1021/jm00052a006

Reference yield: 95.0%

: 147776-54-3
5-n-butyl-2,4-dihydro-2-(3-nitrophenyl)-4-[(2'-sulfamoylbiphenyl-4-yl)methyl]-3H-1,2,4-triazol-3-one

: 118-91-2
ortho-chlorobenzoic acid

: 147776-55-4
5-n-butyl-4-[[2'-[N-(2-chlorobenzoyl)sulfamoyl]biphenyl-4-yl]methyl]-2,4-dihydro-2-(3-nitrophenyl)-3H-1,2,4-triazol-3-one

Guidance literature:: With CDI; 1,8-diazabicyclo[5.4.0]undec-7-ene;

Reference yield:

: 147776-52-1
5-n-butyl-2,4-dihydro-2-(3-nitrophenyl)-3H-1,2,4-triazol-3-one

: 147776-55-4
5-n-butyl-4-[[2'-[N-(2-chlorobenzoyl)sulfamoyl]biphenyl-4-yl]methyl]-2,4-dihydro-2-(3-nitrophenyl)-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 50 deg C, 1 h, 2.) DMF, 50 deg C, 1.5 h

2: anisole, TFA / Ambient temperature

3: 95 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / tetrahydrofuran / 50 °C

With sodium hydride; methoxybenzene; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1021/jm00052a006