Ethyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate

Base Information

Chemical Name:Ethyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
CAS No.:15854-12-3
Molecular Formula:C15H17 N O4 S
Molecular Weight:307.37
Hs Code.:2934999090
DSSTox Substance ID:DTXSID60352092
Wikidata:Q82129063
ChEMBL ID:CHEMBL2393418
Mol file:15854-12-3.mol

Synonyms:15854-12-3;ethyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate;2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester;aPKC-I;MFCD00499458;Ethyl 2-amino-4-(3,4-dimethoxyphenyl)-3-thiophenecarboxylate;aPKCI;CBMicro_039983;Oprea1_119951;Oprea1_617436;SCHEMBL8288714;CHEMBL2393418;DTXSID60352092;BBL015066;STK018273;AKOS000115406;VS-04827;BIM-0039862.P001;EN300-02305;Z56838372;ethyl2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate;Ethyl 2-amino-4-(3,4-dimethoxyphenyl)-3-thiophenecarboxylate, AldrichCPR

Suppliers and Price of Ethyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylicacidethylester
250mg
$ 210.00

Sigma-Aldrich
Ethyl 2-amino-4-(3,4-dimethoxyphenyl)-3-thiophenecarboxylate Aldrich
1g
$ 168.00

Matrix Scientific
Ethyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
500mg
$ 126.00

Crysdot
Ethyl2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 97%
5g
$ 515.00

Crysdot
Ethyl2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 97%
10g
$ 771.00

Chemenu
ethyl2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 95%
10g
$ 960.00

Chemenu
ethyl2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 95%
5g
$ 600.00

Arctom
Ethyl2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 97%
1g
$ 251.00

American Custom Chemicals Corporation
2-AMINO-4-(3,4-DIMETHOXY-PHENYL)-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER 95.00%
5G
$ 1082.56

American Custom Chemicals Corporation
2-AMINO-4-(3,4-DIMETHOXY-PHENYL)-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER 95.00%
1G
$ 677.91

Total 3 raw suppliers

Chemical Property of Ethyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate

Chemical Property:

Vapor Pressure:7.54E-08mmHg at 25°C
Boiling Point:437.3°Cat760mmHg
PKA:-0.29±0.10(Predicted)
Flash Point:218.3°C
PSA：99.02000
Density:1.234g/cm³
LogP:3.77240
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:307.08782920
Heavy Atom Count:21
Complexity:355

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylicacidethylester ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-41
Safety Statements: 26-39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(SC=C1C2=CC(=C(C=C2)OC)OC)N

Technology Process of Ethyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate

There total 2 articles about Ethyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 105-56-6
ethyl 2-cyanoacetate

: 1131-62-0
1-(3,4-dimethoxyphenyl)ethanone

: 15854-12-3
2-amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester

Guidance literature:: ethyl 2-cyanoacetate; 1-(3,4-dimethoxyphenyl)ethanone; With ammonium acetate; acetic acid; In toluene; Dean-Stark; Reflux;

With sulfur; diethylamine; In ethanol; at 50 ℃; for 3h;
DOI:10.1016/j.bmcl.2013.03.019