2-Fluoro-5-methylthiophene

Base Information

• Chemical Name: 2-Fluoro-5-methylthiophene
• CAS No.: 1481-00-1
• Molecular Formula: C5H5FS
• Molecular Weight: 116.15700
• Hs Code.: 2934999090
• Mol file: 1481-00-1.mol

Synonyms:GVEGDZKHUFWMBO-UHFFFAOYSA;2-Fluor-5-methyl-thiophen;2-fluoro-5-methyl-thiophene;

Chemical Property of 2-Fluoro-5-methylthiophene

Chemical Property:

• PSA: 28.24000
• LogP: 2.19560

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoro-5-methylthiophene

There total 3 articles about 2-Fluoro-5-methylthiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

2-methylthiophene-5-carboxylic acid (1918-79-2) → 2-Fluor-5-methyl-thiophen (1481-00-1)

Guidance literature:

With potassium fluoride; Selectfluor; In cyclohexane; water; at 70 ℃; for 15h;

DOI:10.1021/acs.orglett.7b00335

Reference yield:

bis(5-methyl-2-thienyl)iodonium trifluoroacetate (1190072-80-0) → 2-Fluor-5-methyl-thiophen (1481-00-1)

Guidance literature:

With potassium fluoride; In N,N-dimethyl-formamide;

DOI:10.1016/j.jfluchem.2009.02.001

Reference yield:

→ 2-Fluor-5-methyl-thiophen (1481-00-1)

Guidance literature:

2-Methyl-thiophen, Perchlorylfluorid, Ethyllithium;

upstream raw materials:

bis(5-methyl-2-thienyl)iodonium trifluoroacetate

2-methylthiophene-5-carboxylic acid

Refernces

• 1、 Onys'ko, Petro P.,Kim, Tetyana V.,Kiseleva, Olena I.,Rassukana, Yuliya V.,Gakh, Andrei A.. "Cascade iodination-fluorination synthesis of 2-fluorothiophene and 5-fluoro-2-thienyliodonium salts". body text. p. 501 - 504. Retrieved 2010/01/14.