1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[4-[[2-[2-(methoxycarbonyl)-1H-pyrrol-1-yl]-1-oxo-3-( 2-thienyl)propyl]amino]phenyl]methyl]-, methyl ester, (S)-

Base Information

Chemical Name:1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[4-[[2-[2-(methoxycarbonyl)-1H-pyrrol-1-yl]-1-oxo-3-( 2-thienyl)propyl]amino]phenyl]methyl]-, methyl ester, (S)-
CAS No.:148549-79-5
Molecular Formula:C29H31ClN4O5S
Molecular Weight:583.108
Hs Code.:
Mol file:148549-79-5.mol

1H-Imidazole-5-carboxylic acid,
2-butyl-4-chloro-1-[[4-[[2-[2-(methoxycarbonyl)-1H-pyrrol-1-yl]-1-oxo-3-(
2-thienyl)propyl]amino]phenyl]methyl]-, methyl ester, (S)-

Synonyms:

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Chemical Property of 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[4-[[2-[2-(methoxycarbonyl)-1H-pyrrol-1-yl]-1-oxo-3-( 2-thienyl)propyl]amino]phenyl]methyl]-, methyl ester, (S)-

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Technology Process of 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[4-[[2-[2-(methoxycarbonyl)-1H-pyrrol-1-yl]-1-oxo-3-( 2-thienyl)propyl]amino]phenyl]methyl]-, methyl ester, (S)-

There total 6 articles about 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[4-[[2-[2-(methoxycarbonyl)-1H-pyrrol-1-yl]-1-oxo-3-( 2-thienyl)propyl]amino]phenyl]methyl]-, methyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124750-71-6
2-butyl-4-chloro-1H-imidazole-5-carboxylic acid,methyl ester

: 148549-79-5
2-Butyl-5-chloro-3-{4-[(S)-2-(2-methoxycarbonyl-pyrrol-1-yl)-3-thiophen-2-yl-propionylamino]-benzyl}-3H-imidazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: base

2: H₂ / Raney Ni / tetrahydrofuran / 23 °C / 2585.7 Torr

3: (CH₃)3CCOCl, DMAP / tetrahydrofuran

With dmap; hydrogen; pivaloyl chloride; nickel; In tetrahydrofuran;
DOI:10.1021/jm00064a007

Reference yield:

: 148549-71-7
methyl 2-butyl-4-chloro-3-<(4-nitrophenyl)methyl>-3H-imidazole-5-carboxylate

: 148549-79-5
2-Butyl-5-chloro-3-{4-[(S)-2-(2-methoxycarbonyl-pyrrol-1-yl)-3-thiophen-2-yl-propionylamino]-benzyl}-3H-imidazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Raney Ni / tetrahydrofuran / 23 °C / 2585.7 Torr

2: (CH₃)3CCOCl, DMAP / tetrahydrofuran

With dmap; hydrogen; pivaloyl chloride; nickel; In tetrahydrofuran;
DOI:10.1021/jm00064a007

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 148549-79-5
2-Butyl-5-chloro-3-{4-[(S)-2-(2-methoxycarbonyl-pyrrol-1-yl)-3-thiophen-2-yl-propionylamino]-benzyl}-3H-imidazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: base

2: H₂ / Raney Ni / tetrahydrofuran / 23 °C / 2585.7 Torr

3: (CH₃)3CCOCl, DMAP / tetrahydrofuran

With dmap; hydrogen; pivaloyl chloride; nickel; In tetrahydrofuran;
DOI:10.1021/jm00064a007