2-[(4-methylpiperazin-1-yl)methyl]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one

Base Information

Chemical Name:2-[(4-methylpiperazin-1-yl)methyl]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
CAS No.:20886-99-1
Molecular Formula:C₁₆H₂₂N₄OS
Molecular Weight:318.443
Hs Code.:

Synonyms:[1]Benzothieno[2,3-d]pyrimidin-4(3H)-one,5,6,7,8-tetrahydro-2-[(4-methyl-1-piperazinyl)methyl]- (8CI)

Suppliers and Price of 2-[(4-methylpiperazin-1-yl)methyl]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-[(4-METHYLPIPERAZIN-1-YL)METHYL]-5,6,7,8-TETRAHYDRO-3H-[1]BENZOTHIOLO[2,3-D]PYRIMIDIN-4-ONE 95.00%
5MG
$ 505.46

Total 3 raw suppliers

Chemical Property of 2-[(4-methylpiperazin-1-yl)methyl]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one

Chemical Property:

PSA：80.73000
Density:1.46g/cm³
LogP:1.89890

Purity/Quality:

99% ^*data from raw suppliers

2-[(4-METHYLPIPERAZIN-1-YL)METHYL]-5,6,7,8-TETRAHYDRO-3H-[1]BENZOTHIOLO[2,3-D]PYRIMIDIN-4-ONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-[(4-methylpiperazin-1-yl)methyl]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one

There total 4 articles about 2-[(4-methylpiperazin-1-yl)methyl]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.3%

: 109-01-3
1-methyl-piperazine

: 89567-03-3
2-(chloromethyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one

: 20886-99-1
2-[(4-methylpiperazin-1-yl)methyl]-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-one

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 5 - 20 ℃;
DOI:10.1080/00397911.2010.515357

Reference yield:

: 20886-97-9
2-[2-(4-methyl-piperazin-1-yl)-acetylamino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide

: 20886-99-1
2-[(4-methylpiperazin-1-yl)methyl]-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-one

Guidance literature:: In glycerol; at 180 ℃;
DOI:10.1007/BF00904346

Reference yield:

: 4506-71-2
ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

: 20886-99-1
2-[(4-methylpiperazin-1-yl)methyl]-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 3 h / 50 °C

2: triethylamine / N,N-dimethyl-formamide / 5 - 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1080/00397911.2010.515357