[(2-Methoxyphenyl)methyl](phenyl)phosphane

Base Information

• Chemical Name: [(2-Methoxyphenyl)methyl](phenyl)phosphane
• CAS No.: 1485-88-7
• Molecular Formula: C₁₄H₁₅OP
• Molecular Weight: 230.246
• DSSTox Substance ID: DTXSID00591544
• Wikidata: Q82485331
• Mol file: 1485-88-7.mol

Synonyms:[(2-Methoxyphenyl)methyl](phenyl)phosphane;SCHEMBL1451079;DTXSID00591544;DB-009313

Chemical Property of [(2-Methoxyphenyl)methyl](phenyl)phosphane

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 230.086052095
• Heavy Atom Count: 16
• Complexity: 189

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1CPC2=CC=CC=C2

Technology Process of [(2-Methoxyphenyl)methyl](phenyl)phosphane

There total 49 articles about [(2-Methoxyphenyl)methyl](phenyl)phosphane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(2-methoxyphenyl)(methyl)(phenyl)phosphine oxide (20663-35-8,35143-99-8,39600-39-0,99396-68-6) → (o-methoxyphenyl)methylphenylphosphine (1485-88-7,35144-01-5,65337-14-6,120203-45-4)

Guidance literature:

With trichlorosilane; In benzene; for 24h; Heating;

DOI:10.1021/ja072925l

Reference yield: 85.0%

(Rp)-(2-methoxyphenyl)methylphenylphosphine oxide (35143-99-8) → (SP)-(o-methoxyphenyl)(methyl)phenylphosphine (1485-88-7,35144-01-5,65337-14-6)

Guidance literature:

With trichlorosilane; triphenylphosphine; In tetrahydrofuran; toluene; at 80 ℃; for 3h;

DOI:10.1021/ol048227c

Reference yield:

borane-THF (14044-65-6) + (2-methoxyphenyl)(methyl)(phenyl)phosphine oxide (20663-35-8,35143-99-8,39600-39-0,99396-68-6) → (R(P))-(o-anisyl)(methyl)(phenyl)phosphine-P-borane (129212-59-5,97764-41-5,97858-63-4) + (o-methoxyphenyl)methylphenylphosphine (1485-88-7,35144-01-5,65337-14-6,120203-45-4)

Guidance literature:

With titanium(IV) isopropylate; In tetrahydrofuran; toluene; at 50 ℃; for 48h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tet.2021.132057

upstream raw materials:

Dichlorophenylphosphine

(CH₃OC₆H₄)2Cd

(2-methoxyphenyl)(methyl)(phenyl)phosphine oxide

phenylphosphonous acid dimethyl ester

Downstream raw materials:

Dimethyl-<2'-methoxy-phenyl>-phenyl-phosphonium-2,4-dinitrobenzol-sulfonat

(R_p)-(2-methoxyphenyl)methylphenylphosphine oxide

(S_p)-(2-methoxyphenyl)methylphenylphosphine oxide

FeCH₃(CO)2(C₆H₅P(C₆H₄OCH₃)(CH₃))(P(CH₃)3)2⁽¹⁺⁾*B(C₆H₅)4^(1-)=(FeCH₃(CO)2(C₆H₅P(C₆H₄OCH₃)(CH₃))(P(CH₃)3)2)(B(C₆H₅)4)