2-(Methoxymethyl)thiophene

Base Information

• Chemical Name: 2-(Methoxymethyl)thiophene
• CAS No.: 1487-28-1
• Molecular Formula: C6H8OS
• Molecular Weight: 128.195
• DSSTox Substance ID: DTXSID40437093
• Nikkaji Number: J850.699J
• Wikidata: Q82252466
• Mol file: 1487-28-1.mol

Synonyms:5-Methoxymethyl-thiophene;2-(methoxymethyl)thiophene;1487-28-1;2-methoxymethylthiophene;Thiophene, 2-(methoxymethyl)-;SCHEMBL862369;SCHEMBL10205398;DTXSID40437093;BMZQEYGEQALEIO-UHFFFAOYSA-N;MFCD22054632;CS-0196397;E92127;EN300-7597129

Chemical Property of 2-(Methoxymethyl)thiophene

Chemical Property:

• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 128.02958605
• Heavy Atom Count: 8
• Complexity: 65.5

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COCC1=CC=CS1

Technology Process of 2-(Methoxymethyl)thiophene

There total 1 articles about 2-(Methoxymethyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-thiophenylcarboxylic acid (527-72-0) + thiophene-2-carboxylic acid methyl ester (5380-42-7) + 2-methoxymethyl-thiophene (1487-28-1)

Guidance literature:

With oxygen; cobalt(II) acetate; sodium bromide; In acetic acid; at 95 ℃; for 1h;

DOI:10.1007/BF00557743

Reference yield: 67.0%

2-methoxymethyl-thiophene (1487-28-1) + p-Chlorothiophenol (106-54-7) → S-(4-chlorophenyl) thiophene-2-carbothioate (216453-27-9)

Guidance literature:

With di-tert-butyl peroxide; In neat (no solvent); at 120 ℃; for 24h; Sealed tube;

DOI:10.1039/c4ob02250e

Reference yield: 31.0%

2-methoxymethyl-thiophene (1487-28-1) → thiophene-2-carbonitrile (1003-31-2)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; ammonium acetate; oxygen; nitric acid; In acetic acid; at 50 ℃; for 20h; Autoclave;

DOI:10.1055/s-0037-1611062

Downstream raw materials:

thiophene-2-carbaldehyde

2-thiophenylcarboxylic acid

thiophene-2-carboxylic acid methyl ester

N-(2-((5-(methoxymethyl)thiophen-2-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-phenyloxazole-4-carboxamide