2-(Morpholin-4-yl)cyclohexan-1-one

Base Information

• Chemical Name: 2-(Morpholin-4-yl)cyclohexan-1-one
• CAS No.: 14909-84-3
• Molecular Formula: C10H17NO2
• Molecular Weight: 183.25
• Mol file: 14909-84-3.mol

Synonyms:2-(4-Morpholinyl)cyclohexanone;2-Morpholino-cyclohexanon;2-morpholino-cyclohexanone;(2R)/(2S)-2-(4-morpholinyl)cyclohexan-1-one;2-morpholin-4-yl-cyclohexanone;

Chemical Property of 2-(Morpholin-4-yl)cyclohexan-1-one

Chemical Property:

• Boiling Point: 148 °C(Press: 20 Torr)
• PKA: 5.50±0.20(Predicted)
• PSA: 29.54000
• Density: 1.097 g/cm3
• LogP: 0.76820

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(Morpholin-4-yl)cyclohexan-1-one

There total 8 articles about 2-(Morpholin-4-yl)cyclohexan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

trans-2-morpholinocyclohexanol (14909-79-6) → 2-(4-morpholinyl)cyclohexanone (14909-84-3)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -60 - 20 ℃;

DOI:10.1021/jm0604528

Reference yield: 94.0%

morpholine (110-91-8,99108-56-2) + Sulfuric acid 4-nitro-phenyl ester 2-oxo-cyclohexyl ester → 2-(4-morpholinyl)cyclohexanone (14909-84-3)

Guidance literature:

In dichloromethane; for 64h; Ambient temperature;

DOI:10.1021/jo00352a002

Reference yield: 74.0%

morpholine (110-91-8,99108-56-2) + 1-nitrocyclohexene oxide (109314-65-0) → 2-(4-morpholinyl)cyclohexanone (14909-84-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 15 ℃; for 0.166667h;

DOI:10.1016/S0040-4020(01)81002-4

upstream raw materials:

morpholine

2-Chlorocyclohexanone

1-nitrocyclohexene oxide

4-cyclohexen-1-ylmorpholine

Downstream raw materials:

N-(6-Chloro-pyridazin-3-yl)-N'-[2-morpholin-4-yl-cyclohex-(E)-ylidene]-hydrazine

2-morpholino-2-phenylcyclohexan-1-one

cis/trans-2-(4-morpholinyl)cyclohexan-1-ol

(1S,2R)-2-(morpholin-4-yl)cyclohexanol