Technology Process of 2-Butynoic acid, 4-(phenylmethoxy)-, methyl ester
There total 4 articles about 2-Butynoic acid, 4-(phenylmethoxy)-, methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Benzyl propargyl ether;
With
n-butyllithium;
In
tetrahydrofuran;
at -78 - -20 ℃;
methyl chloroformate;
In
tetrahydrofuran;
at -78 - 20 ℃;
DOI:10.1021/jo0341362
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) oxalyl chloride, DMSO, 2.) triethylamine / 1.) hexane, CH2Cl2, -78 deg C, 10 min, 2.) -78 deg C to room temperature
2: 1.) triphenylphosphine, zinc / 1.) CH2Cl2, room temperature, 12 h, 2.) CH2Cl2, room temperature, 1.5 h
3: 1.) butyllithium / 1.) THF, hexane, -78 deg C, 1 h, 2.) -78 deg C to room temperature
With
n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triethylamine; triphenylphosphine; zinc;
DOI:10.1016/0008-6215(93)80096-W
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) triphenylphosphine, zinc / 1.) CH2Cl2, room temperature, 12 h, 2.) CH2Cl2, room temperature, 1.5 h
2: 1.) butyllithium / 1.) THF, hexane, -78 deg C, 1 h, 2.) -78 deg C to room temperature
With
n-butyllithium; triphenylphosphine; zinc;
DOI:10.1016/0008-6215(93)80096-W
