1-Cyclopentyl-2-methoxyethan-1-one

Base Information

• Chemical Name: 1-Cyclopentyl-2-methoxyethan-1-one
• CAS No.: 14966-80-4
• Molecular Formula: C₈H₁₄O₂
• Molecular Weight: 142.198
• DSSTox Substance ID: DTXSID70518460
• Wikidata: Q82381154
• Mol file: 14966-80-4.mol

Synonyms:1-cyclopentyl-2-methoxyethan-1-one;1-Cyclopentyl-2-methoxyethanone;14966-80-4;Ethanone, 1-cyclopentyl-2-methoxy-;DTXSID70518460;AKOS010815270;EN300-120418;G41489

Chemical Property of 1-Cyclopentyl-2-methoxyethan-1-one

Chemical Property:

• PSA: 26.30000
• LogP: 1.39210
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 142.099379685
• Heavy Atom Count: 10
• Complexity: 114

Purity/Quality:

99% ^*data from raw suppliers

1-Cyclopentyl-2-methoxyethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC(=O)C1CCCC1

Technology Process of 1-Cyclopentyl-2-methoxyethan-1-one

There total 4 articles about 1-Cyclopentyl-2-methoxyethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-methoxyacetate (3938-96-3) + cyclopentylmagnesium chloride (32916-51-1) → 1-cyclopentyl-2-methoxyethanone (14966-80-4)

Guidance literature:

cyclopentylmagnesium chloride; With titanium(IV) isopropylate; In diethyl ether; at -78 - -50 ℃; for 0.216667h;

ethyl 2-methoxyacetate; In diethyl ether; at -50 - -30 ℃; for 0.5h;

With hydrogenchloride; In diethyl ether; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2006.08.117

Reference yield:

2-methoxyacetonitrile (1738-36-9) + cyclopentylmagnesium chloride (32916-51-1) → 1-cyclopentyl-2-methoxyethanone (14966-80-4)

Guidance literature:

With diethyl ether; anschliessend Hydrolysen;

DOI:10.1021/jo01202a010

Reference yield:

2-methoxyacetonitrile (1738-36-9) + cyclopentylmagnesium bromide (33240-34-5) → 1-cyclopentyl-2-methoxyethanone (14966-80-4)

Guidance literature:

With diethyl ether; anschliessend Hydrolysen;

DOI:10.1021/jo01202a010

upstream raw materials:

2-methoxyacetonitrile

cyclopentylmagnesium chloride

cyclopentylmagnesium bromide

tricyclopentylborane