Quinoline, 5,8-dimethoxy-4-(2-nitrophenyl)-

Base Information

Chemical Name:Quinoline, 5,8-dimethoxy-4-(2-nitrophenyl)-
CAS No.:150127-37-0
Molecular Formula:C17H14N2O4
Molecular Weight:310.309
Hs Code.:
DSSTox Substance ID:DTXSID10451049
Wikidata:Q82270911
Mol file:150127-37-0.mol

Synonyms:Quinoline, 5,8-dimethoxy-4-(2-nitrophenyl)-;150127-37-0;DTXSID10451049

Suppliers and Price of Quinoline, 5,8-dimethoxy-4-(2-nitrophenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Quinoline, 5,8-dimethoxy-4-(2-nitrophenyl)-

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:310.09535693
Heavy Atom Count:23
Complexity:414

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C2C(=CC=NC2=C(C=C1)OC)C3=CC=CC=C3[N+](=O)[O-]

Technology Process of Quinoline, 5,8-dimethoxy-4-(2-nitrophenyl)-

There total 3 articles about Quinoline, 5,8-dimethoxy-4-(2-nitrophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 150127-36-9
2-trifluoromethanesulfonyl-5,8-dimethoxy-4-(2-nitrophenyl)quinoline

: 150127-37-0
5,8-dimethoxy-4-(2-nitrophenyl)quinoline

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; formic acid; palladium diacetate; triethylamine; In N,N-dimethyl-formamide; at 0 - 60 ℃; for 2h;

Reference yield: 84.0%

: 114552-21-5
5,8-dimethoxy-4-trifluoromethansulfonyloxyquinoline

: 76074-18-5
trimethyl-(2-nitro-phenyl)-stannane

: 150127-37-0
5,8-dimethoxy-4-(2-nitrophenyl)quinoline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) bromide; In 1,4-dioxane; at 90 ℃; for 1.5h;
DOI:10.1016/j.bmc.2004.09.021

Reference yield:

: 121998-60-5
5,8-Dimethoxy-4-(2-nitrophenyl)-2(1H)-quinolinone

: 150127-37-0
5,8-dimethoxy-4-(2-nitrophenyl)quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / Et₃N / CH₂Cl₂ / 0.5 h / -20 °C

2: 92 percent / 99percent formic acid, Et₃N, palladium acetate, 1,1'-bis(diphenylphosphino)ferrocene / dimethylformamide / 2 h / 0 - 60 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; formic acid; palladium diacetate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;