1-Azaspiro(5.5)undecan-8-ol, 7-(1-buten-3-ynyl)-2-(4-pentynyl)-, (6R-(6alpha(R*),7beta(Z),8alpha))-

Base Information

Chemical Name:1-Azaspiro(5.5)undecan-8-ol, 7-(1-buten-3-ynyl)-2-(4-pentynyl)-, (6R-(6alpha(R*),7beta(Z),8alpha))-
CAS No.:63983-63-1
Molecular Formula:C₁₉H₂₇NO
Molecular Weight:285.429
Hs Code.:

Synonyms:63983-63-1;l-Allodihydrohistrionicotoxin;Histrionicotoxin, allodihydro-;Allodihydrohistrionicotoxin;HTX 285C;1-Azaspiro(5.5)undecan-8-ol, 7-(1-buten-3-ynyl)-2-(4-pentynyl)-, (6R-(6alpha(R*),7beta(Z),8alpha))-;11-[(E)-but-1-en-3-ynyl]-2-pent-4-ynyl-1-azaspiro[5.5]undecan-10-ol;(2R,6R,7alpha,8beta)-7-[(Z)-1-Buten-3-ynyl]-2-(4-pentynyl)-1-azaspiro[5.5]undecan-8-ol;SCHEMBL3146131;1-Azaspiro[5.5]undecan-8-ol, 7-(1-buten-3-ynyl)-2-(4-pentynyl)-,[6R-[6.alpha.(R*),7.beta.(Z),8.alpha.]]-

Suppliers and Price of 1-Azaspiro(5.5)undecan-8-ol, 7-(1-buten-3-ynyl)-2-(4-pentynyl)-, (6R-(6alpha(R*),7beta(Z),8alpha))-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 1-Azaspiro(5.5)undecan-8-ol, 7-(1-buten-3-ynyl)-2-(4-pentynyl)-, (6R-(6alpha(R*),7beta(Z),8alpha))-

Chemical Property:

Vapor Pressure:2.39E-08mmHg at 25°C
Boiling Point:407.7°C at 760 mmHg
Flash Point:76°C
PSA：32.26000
Density:1.04g/cm³
LogP:3.35000
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:285.209264485
Heavy Atom Count:21
Complexity:462

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C#CCCCC1CCCC2(N1)CCCC(C2C=CC#C)O
Isomeric SMILES:C#CCCCC1CCCC2(N1)CCCC(C2/C=C/C#C)O

Technology Process of 1-Azaspiro(5.5)undecan-8-ol, 7-(1-buten-3-ynyl)-2-(4-pentynyl)-, (6R-(6alpha(R*),7beta(Z),8alpha))-

There total 11 articles about 1-Azaspiro(5.5)undecan-8-ol, 7-(1-buten-3-ynyl)-2-(4-pentynyl)-, (6R-(6alpha(R*),7beta(Z),8alpha))- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 460710-45-6
16,20-bis(trimethylsilyl)histrionicotoxin 285C

: 63983-63-1
allodihydrohistrionicotoxin

Guidance literature:: With potassium carbonate; In methanol; at 25 ℃; for 17h;
DOI:10.1039/b111514f

Reference yield:

: 460710-37-6
(2S,6R,7S,8S)-(1Z)-2-(5'-trimethylsilylpent-4'-ynl)-7-(4''-trimethylsilyl-but-1''-en-3''-yn-1''-yl)-1-aza-12-oxatricyclo[5.4.1^6,8.0]undecane

: 63983-63-1
allodihydrohistrionicotoxin

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / Zn; AcOH / 0.5 h

2: 88 percent / K₂CO₃ / methanol / 17 h / 25 °C

With potassium carbonate; acetic acid; zinc; In methanol;
DOI:10.1039/b111514f

Reference yield:

: (2S,6R,7S,8S)-(1''-Z)-2-(5'-trimethylsilyl-1'-hydroxypent-4'-ynyl)-7-(4''-trimethylsilyl-but-1''-en-3''-yn-1''-yl)-1-aza-12-oxatricyclo[5.4.1^6,8.0]undecane

: 63983-63-1
allodihydrohistrionicotoxin

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / 1.5 h / 0 - 20 °C

1.2: 1 h

1.3: 83 percent / tetrahydrofuran / 1.5 h

2.1: Bu₃SnH; AIBN / benzene / 80 °C

3.1: 97 percent / Zn; AcOH / 0.5 h

4.1: 88 percent / K₂CO₃ / methanol / 17 h / 25 °C

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; potassium carbonate; acetic acid; zinc; In methanol; benzene;
DOI:10.1039/b111514f