6-Hydroxy-1H-indole-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: 6-Hydroxy-1H-indole-2-carboxylic acid ethyl ester
• CAS No.: 15050-03-0
• Molecular Formula: C11H11NO3
• Molecular Weight: 205.21000
• Hs Code.: 2933990090
• Mol file: 15050-03-0.mol

Synonyms:2-Dimethylamino-6-benzothiazolol;2-ethoxycarbonyl-6-hydroxyindole;Polyglutamine Aggregation Inhibitor,PGL-137;Ethyl-6-hydroxyindol-2-carboxylat;6-Hydroxy-2-dimethylamino-benzothiazol;6-hydroxy-1H-indole-2-carboxylic acid ethyl ester;2-Dimethylamino-6-hydroxybenzothiazole;6-Hydroxy-indol-2-carbonsaeureethylester;ethyl-6-hydroxyindole-2-carboxylate;6-hydroxy-2-ethoxycarbonylindole;6-hydroxy-indole-2-carboxylic acid ethyl ester;

Chemical Property of 6-Hydroxy-1H-indole-2-carboxylic acid ethyl ester

Chemical Property:

• Vapor Pressure: 2.54E-07mmHg at 25°C
• Boiling Point: 410.4oC at 760 mmHg
• PKA: 9.33±0.40(Predicted)
• Flash Point: 202oC
• PSA: 62.32000
• Density: 1.326g/cm3
• LogP: 2.05020

Purity/Quality:

95% ^*data from raw suppliers

Ethyl6-hydroxy-1H-indole-2-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Hydroxy-1H-indole-2-carboxylic acid ethyl ester

There total 2 articles about 6-Hydroxy-1H-indole-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-oxo-propionic acid ethyl ester (617-35-6) + m-Hydroxyaniline (591-27-5) → ethyl 6-hydroxy-1H-indole-2-carboxylate (15050-03-0)

Guidance literature:

With oxygen; palladium diacetate; acetic acid; In dimethyl sulfoxide; at 70 ℃; for 18h; under 760.051 Torr; regioselective reaction; Schlenk technique; Molecular sieve;

DOI:10.1021/acs.joc.8b02180

Reference yield:

→ ethyl 6-hydroxy-1H-indole-2-carboxylate (15050-03-0)

Guidance literature:

Dibromindol XII, H2;

DOI:10.1021/bi00845a023

upstream raw materials:

2-oxo-propionic acid ethyl ester

m-Hydroxyaniline

Refernces

• 1、 Wilchek et al.. "-". . p. 3349. Retrieved 1967.
• 2、 Ren, Long,Nan, Guanglei,Wang, Yongcheng,Xiao, Zhiyan. "Carboxylic Acid-Promoted Single-Step Indole Construction from Simple Anilines and Ketones via Aerobic Cross-Dehydrogenative Coupling". . p. 14472 - 14488. Retrieved 2018/11/23.
• 3、 -. "Process for dyeing keratin fibres with a monohydroxyindole associated with an iodide and hydrogen peroxide". . . Retrieved 2008/06/13.