N'-[7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]-N,N-dimethylmethanimidamide

Base Information

Chemical Name:N'-[7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]-N,N-dimethylmethanimidamide
CAS No.:57881-19-3
Molecular Formula:C14H19 N5 O4
Molecular Weight:321.3318
Hs Code.:
NSC Number:140858
DSSTox Substance ID:DTXSID80422140

Synonyms:NSC140858;57881-19-3;DTXSID80422140;NSC-140858

Suppliers and Price of N'-[7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]-N,N-dimethylmethanimidamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of N'-[7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]-N,N-dimethylmethanimidamide

Chemical Property:

Vapor Pressure:7.93E-16mmHg at 25°C
Boiling Point:611.9°Cat760mmHg
Flash Point:323.9°C
Density:1.56g/cm³
XLogP3:-1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:321.14370410
Heavy Atom Count:23
Complexity:437

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)C=NC1=C2C=CN(C2=NC=N1)C3C(C(C(O3)CO)O)O
Isomeric SMILES:CN(C)/C=N\C1=C2C=CN(C2=NC=N1)C3C(C(C(O3)CO)O)O

Technology Process of N'-[7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]-N,N-dimethylmethanimidamide

There total 1 articles about N'-[7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]-N,N-dimethylmethanimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 69-33-0
tubercidin

: 1188-33-6
N,N-dimethylformamide diethyl diacetal

: 57881-19-3
4-<<(dimethylamino)methylidene>amino>-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine

Guidance literature:: In N,N-dimethyl-formamide; at 50 ℃; for 1h;
DOI:10.1002/hlca.19930760502

Reference yield: 81.0%

: 57881-19-3
4-<<(dimethylamino)methylidene>amino>-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine

: 14470-28-1
mono-4-methoxytrityl chloride

: 57881-44-4
4-<<(dimethylamino)methylidene>amino>-7-<5-O-<(4-methoxytriphenyl)methyl>-β-D-ribofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In pyridine; at 50 ℃; for 3h;
DOI:10.1002/hlca.19930760502

Reference yield:

: 57881-19-3
4-<<(dimethylamino)methylidene>amino>-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine

: 151512-09-3
4-<<(dimethylamino)methylidene>amino>-7-<3-O-<(1,1-dimethylethyl)dimethylsilyl>-5-O-<(4-methoxytriphenyl)methyl>-β-D-ribofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / (i-Pr)2NEt / pyridine / 3 h / 50 °C

2: 17 percent / AgNO₃ / pyridine; tetrahydrofuran / 24 h

With silver nitrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine;
DOI:10.1002/hlca.19930760502