Benzamide, 2,3-dimethoxy-N-phenyl-

Base Information

• Chemical Name: Benzamide, 2,3-dimethoxy-N-phenyl-
• CAS No.: 1522-49-2
• Molecular Formula: C15H15NO3
• Molecular Weight: 257.289
• Mol file: 1522-49-2.mol

Synonyms:2,3-Dimethoxy-benzanilid;2,3-Dimethoxy-N-phenyl-benzamide;

Chemical Property of Benzamide, 2,3-dimethoxy-N-phenyl-

Chemical Property:

• Melting Point: 87 - 89 °C (acetonitrile)
• PSA: 47.56000
• LogP: 3.02910

Purity/Quality:

95% ^*data from raw suppliers

2,3-DIMETHOXY-N-PHENYL-BENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzamide, 2,3-dimethoxy-N-phenyl-

There total 3 articles about Benzamide, 2,3-dimethoxy-N-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2,3-dimethoxybenzoic acid (1521-38-6) + aniline (62-53-3) → 2,3-dimethoxy-N-phenylbenzamide (1522-49-2)

Guidance literature:

With diethyl chlorophosphate; triethylamine; In dichloromethane; Ambient temperature;

Reference yield: 73.0%

aniline (62-53-3) + 2,3-dimethoxybenzoyl chloride (7169-06-4) → 2,3-dimethoxy-N-phenylbenzamide (1522-49-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 15h;

DOI:10.2174/1570178613666151230210931

Reference yield:

2,3-dimethoxybenzoic acid (1521-38-6) → 2,3-dimethoxy-N-phenylbenzamide (1522-49-2)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride

2: triethylamine / tetrahydrofuran / 15 h / 20 °C

With thionyl chloride; triethylamine; In tetrahydrofuran;

DOI:10.2174/1570178613666151230210931

upstream raw materials:

2,3-dimethoxybenzoic acid

aniline

2,3-dimethoxybenzoyl chloride