(2R,4S)-1-Boc-2-methyl-4-hydroxypiperidine

Base Information

• Chemical Name: (2R,4S)-1-Boc-2-methyl-4-hydroxypiperidine
• CAS No.: 152491-46-8
• Molecular Formula: C₁₁H₂₁NO₃
• Molecular Weight: 215.293
• DSSTox Substance ID: DTXSID201149596
• Mol file: 152491-46-8.mol

Synonyms:790668-06-3;(2R,4S)-1-BOC-2-METHYL-4-HYDROXYPIPERIDINE;152491-46-8;tert-butyl (2R,4S)-4-hydroxy-2-methylpiperidine-1-carboxylate;(2R,4S)-rel-tert-Butyl 4-hydroxy-2-methylpiperidine-1-carboxylate;(2R,4S)-tert-Butyl 4-hydroxy-2-methylpiperidine-1-carboxylate;(trans)-tert-butyl 4-hydroxy-2-methylpiperidine-1-carboxylate;1-Piperidinecarboxylicacid,4-hydroxy-2-methyl-,1,1-dimethylethylester,(2R,4S)-(9CI);MFCD22415237;trans-1-Boc-4-Hydroxy-2-methylpiperidine;SCHEMBL9312524;RCXJVQLRZJXWNM-BDAKNGLRSA-N;DTXSID201149596;AMY34471;CGA49146;AKOS025289788;AS-34681;trans 1-CBZ-2-METHYL-PIPERIDIN-4-OL;CS-0048630;(2R,4S)-1-Boc-4-Hydroxy-2-Methylpiperidine;A864927;A883903;tert-butyl (2r,4s)-4-hydroxy-2-methyl-1-piperidinecarboxylate;(2R,4S)-rel-tert-Butyl4-hydroxy-2-methylpiperidine-1-carboxylate;rel-1,1-Dimethylethyl (2R,4S)-4-hydroxy-2-methyl-1-piperidinecarboxylate

Chemical Property of (2R,4S)-1-Boc-2-methyl-4-hydroxypiperidine

Chemical Property:

• Storage Temp.: 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 215.15214353
• Heavy Atom Count: 15
• Complexity: 235

Purity/Quality:

97% ^*data from raw suppliers

(trans)-tert-Butyl 4-hydroxy-2-methylpiperidine-1-carboxylate 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1CC(CCN1C(=O)OC(C)(C)C)O
• Isomeric SMILES: C[C@@H]1C[C@H](CCN1C(=O)OC(C)(C)C)O

Technology Process of (2R,4S)-1-Boc-2-methyl-4-hydroxypiperidine

There total 23 articles about (2R,4S)-1-Boc-2-methyl-4-hydroxypiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 2-methyl-4-oxopiperidine-1-carboxylate (190906-92-4) → tert-butyl 4-hydroxy-2-methylpiperidine-1-carboxylate (208046-23-5,152491-46-8)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 3.5h; Inert atmosphere;

Reference yield: 95.0%

(S)-2-methyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester (790667-49-1) → (2S)-tert-butyl 4-hydroxy-2-methylpiperidine-1-carboxylate (152491-46-8)

Guidance literature:

With methanol; sodium tetrahydroborate; at 20 ℃;

Reference yield: 81.0%

(S)-2-methyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester (790667-49-1) → tert-butyl (2S,4S)-4-hydroxy-2-methyl-piperidine-1-carboxylate (790667-99-1,152491-46-8)

Guidance literature:

With potassium dihydrogenphosphate; D-glucose; sodium hydrogencarbonate; sodium hydroxide; In water; dimethyl sulfoxide; at 20 - 30 ℃; for 16.5h; pH=6.9 - 7.0; Reagent/catalyst; Large scale; Enzymatic reaction;

upstream raw materials:

tert-butyl 2-methyl-4-oxopiperidine-1-carboxylate

(2R)-2-methyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester

(S)-2-methyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester

di-tert-butyl dicarbonate

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