2,2,2-trifluoro-N-(3-formylphenyl)acetamide

Base Information

Chemical Name:2,2,2-trifluoro-N-(3-formylphenyl)acetamide
CAS No.:152528-11-5
Molecular Formula:C₉H₆F₃NO₂
Molecular Weight:217.147
Hs Code.:
European Community (EC) Number:816-825-1
Mol file:152528-11-5.mol

Synonyms:2,2,2-trifluoro-N-(3-formylphenyl)acetamide;152528-11-5;SCHEMBL8756046;VIYRJCIIFVJQJE-UHFFFAOYSA-N;AKOS001184051;CS-0235026;EN300-15195;Z118624356;2,2,2-trifluoro-N-(3-formylphenyl)acetamide, AldrichCPR

Suppliers and Price of 2,2,2-trifluoro-N-(3-formylphenyl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of 2,2,2-trifluoro-N-(3-formylphenyl)acetamide

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:217.03506292
Heavy Atom Count:15
Complexity:252

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC(=C1)NC(=O)C(F)(F)F)C=O

Technology Process of 2,2,2-trifluoro-N-(3-formylphenyl)acetamide

There total 1 articles about 2,2,2-trifluoro-N-(3-formylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53663-37-9
3-aminobenzaldehyde dimethyl acetal

: 407-25-0
trifluoroacetic anhydride

: 152528-11-5
3-(trifluoroacetylamino)benzaldehyde

Guidance literature:: With camphor-10-sulfonic acid; triethylamine; Yield given. Multistep reaction; 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) acetone, 25 deg C, 16 h;
DOI:10.1016/S0968-0896(97)00090-4

Reference yield: 69.0%

: 109-97-7,30604-81-0
pyrrole

: 152528-11-5
3-(trifluoroacetylamino)benzaldehyde

: 5,10,15,20-tetrakis(m-trifluoroacetamido)phenylporphyrin

Guidance literature:: With toluene-4-sulfonic acid; In N,N-dimethyl-formamide;
DOI:10.1142/S1088424619500093

Reference yield:

: 152528-11-5
3-(trifluoroacetylamino)benzaldehyde

: 197725-65-8
3-(3-tert-butyldimethylsilyloxy-1E,5Z-undecadienyl)phenylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaOMe, 2.) aq. HCl / 1.) DMF, MeOH, 60 deg C, 30 min, 2.) THF, 25 deg C, 1 h

2: 1.) t-BuLi, 2.) triisopropylborate

3: 95 percent / imidazole / dimethylformamide / 0.5 h / 25 °C

4: 100 percent / H₂, quinoline / 5percent Pd(2.7percent Pb)-CaCO₃ / ethanol / 0.5 h / 25 °C

5: 100 percent / aq. NaOH / tetrahydrofuran; methanol / 16 h / 25 °C

With 1H-imidazole; quinoline; hydrogenchloride; sodium hydroxide; Triisopropyl borate; hydrogen; tert.-butyl lithium; sodium methylate; Pd(2.7 percent Pb)-CaCO₃; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00090-4