2-(CHLOROMETHYL)-4,4-DIPHENYL-4H-3,1-BENZOXAZINE

Base Information

• Chemical Name: 2-(CHLOROMETHYL)-4,4-DIPHENYL-4H-3,1-BENZOXAZINE
• CAS No.: 153255-65-3
• Molecular Formula: C21H16ClNO
• Molecular Weight: 333.81100
• Mol file: 153255-65-3.mol

Synonyms:2-chloromethyl-4,4-diphenyl-4H-3,1-benzoxazine;2-Chloromethyl-4,4-diphenyl-4H-benzo[d][1,3]oxazine;

Chemical Property of 2-(CHLOROMETHYL)-4,4-DIPHENYL-4H-3,1-BENZOXAZINE

Chemical Property:

• Melting Point: 144 °C (ethanol)
• PSA: 21.59000
• LogP: 4.71310

Purity/Quality:

2-(CHLOROMETHYL)-4,4-DIPHENYL-4H-3,1-BENZOXAZINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(CHLOROMETHYL)-4,4-DIPHENYL-4H-3,1-BENZOXAZINE

There total 2 articles about 2-(CHLOROMETHYL)-4,4-DIPHENYL-4H-3,1-BENZOXAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(2-aminophenyl)diphenylmethanol (52744-72-6) + chloroacetic acid (79-11-8) → 2-chloromethyl-4,4-diphenyl-4H-3,1-benzoxazine (153255-65-3)

Guidance literature:

In chloroform; for 3h; Heating;

DOI:10.1007/BF00529890

Reference yield:

BF4(1-)*C21H16ClNO*H(1+) → 2-chloromethyl-4,4-diphenyl-4H-3,1-benzoxazine (153255-65-3)

Guidance literature:

With potassium hydroxide; In water; for 0.166667h; Heating;

DOI:10.1007/s10593-012-0928-z

Reference yield: 78.0%

4-(methoxymethyl)-6-methyl-3-cyanopyridine-2(1H)-thione (31681-83-1) + 2-chloromethyl-4,4-diphenyl-4H-3,1-benzoxazine (153255-65-3) → 2-(4,4-diphenyl-4H-benzo[d][1,3]oxazin-2-yl)-4-methoxymethyl-6-methyl-thieno[2,3-b]pyridin-3-ylamine

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1007/s11172-005-0208-5

upstream raw materials:

(2-aminophenyl)diphenylmethanol

chloroacetic acid

Downstream raw materials:

1,3,6-tribromo-9-phenylacridine

2-butylsulfanylmethyl-4,4-diphenyl-4H-3,1-benzoxazine

2-diethylaminomethyl-4,4-diphenyl-4H-3,1-benzoxazine

C₂₆H₂₆N₂O