m-PEG4-benzaldehyde

Base Information

• Chemical Name: m-PEG4-benzaldehyde
• CAS No.: 153364-63-7
• Molecular Formula: C14H20O5
• Molecular Weight: 268.31
• Mol file: 153364-63-7.mol

Synonyms:Estradiol 3-benzoate 17-glycolate, 4-(p-(bis(2-chloroethyl)amino)phenyl)butyrate;Estra-1,3,5(10)-triene-3,17-diol, (17-beta)-, 3-benzoate, 17-((4-(4-(bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy)acetate);

Chemical Property of m-PEG4-benzaldehyde

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000
• Solubility.: Soluble in DMSO, DCM, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

m-PEG4-benzaldehyde 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: m-PEG4-benzaldehyde is a small molecule PEG linker containing a terminal benzaldehyde moiety that can react with primary amine groups. PEG4 armr increases the solubility of compounds in aqueous media.
• Uses: m-PEG4-Benzaldehyde is used in the development of biotin-decorated NIR-absorbing nanosheets for targeted photodynamic cancer therapy

Technology Process of m-PEG4-benzaldehyde

There total 11 articles about m-PEG4-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate (62921-74-8,518012-62-9,58320-73-3) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzaldehyde (153364-63-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 48h; Heating;

DOI:10.1021/jm0110690

Reference yield: 86.0%

2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate (62921-74-8,518012-62-9,58320-73-3) + 3,4-dihydroxybenzaldehyde (139-85-5) → 4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzaldehyde (153364-63-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃;

Reference yield: 85.0%

3,6,9-trioxadecyl bromide (72593-77-2,92450-98-1) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzaldehyde (153364-63-7)

Guidance literature:

With potassium carbonate; In water; N,N-dimethyl-formamide; at 65 ℃; Inert atmosphere;

upstream raw materials:

2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate

4-hydroxy-benzaldehyde

8-methoxy-1-(methylsulfonyl)oxy-3,6-dioxaoctane

triethylene glucol monomethyl ether

Downstream raw materials:

α-cyano-N-(2-phenethyl)-p-(1,4,7,10-tetraoxaundecyl)benzylamine