Acetamide, 2,2,2-trifluoro-N-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-

Base Information

Chemical Name:Acetamide, 2,2,2-trifluoro-N-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-
CAS No.:154138-43-9
Molecular Formula:C12H13F3INO3
Molecular Weight:403.14
Hs Code.:
DSSTox Substance ID:DTXSID30450675
Nikkaji Number:J1.662.161G
Wikidata:Q82270482
Mol file:154138-43-9.mol

Synonyms:Acetamide, 2,2,2-trifluoro-N-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-;154138-43-9;DTXSID30450675;PIHKDHLQQJXMKF-UHFFFAOYSA-N;N-(6-Iodo-3,4-dimethoxyphenethyl)trifluoroacetamide

Suppliers and Price of Acetamide, 2,2,2-trifluoro-N-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Acetamide, 2,2,2-trifluoro-N-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:402.98923
Heavy Atom Count:20
Complexity:328

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=C(C(=C1)CCNC(=O)C(F)(F)F)I)OC

Technology Process of Acetamide, 2,2,2-trifluoro-N-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-

There total 3 articles about Acetamide, 2,2,2-trifluoro-N-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 13230-71-2
N-[2-(3,4-dimethoxyphenyl)ethyl]-2,2,2-trifluoroacetamide

: 154138-43-9
2,2,2-trifluoro-N-<2-(2-iodo-4,5-dimethoxyphenyl)ethyl>acetamide

Guidance literature:: With iodine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 6h;
DOI:10.1002/chem.201504378

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 154138-43-9
2,2,2-trifluoro-N-<2-(2-iodo-4,5-dimethoxyphenyl)ethyl>acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: 2.1 g / ICl / CH₂Cl₂ / 20 °C

With Iodine monochloride; triethylamine; In dichloromethane;
DOI:10.1016/j.tet.2007.04.097

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 154138-43-9
2,2,2-trifluoro-N-<2-(2-iodo-4,5-dimethoxyphenyl)ethyl>acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N

2: HIO₃; I₂

With iodine; iodic acid; triethylamine;
DOI:10.1055/s-2003-41502