Carbamic acid, [(1S)-2-[4-(1,1-dimethylethoxy)phenyl]-1-formylethyl]-, 9H-fluoren-9-ylmethyl ester

Base Information

• Chemical Name: Carbamic acid, [(1S)-2-[4-(1,1-dimethylethoxy)phenyl]-1-formylethyl]-, 9H-fluoren-9-ylmethyl ester
• CAS No.: 154524-72-8
• Molecular Formula: C28H29NO4
• Molecular Weight: 443.543
• Mol file: 154524-72-8.mol

Synonyms:Fmoc-Tyr(tBu)-H;(S)-(9H-fluoren-9-yl)methyl(1-(4-(tert-butoxy)phenyl)-3-oxopropan-2-yl)carbamate;[(S)-2-(4-tert-Butoxy-phenyl)-1-formyl-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester;Fmoc-Tyr(tBu)-aldehyde;Fmoc-4-t-butoxy-tyrosinal;N-α-9-fluorenylmethoxycarbonyl-O-tert-butyl-L-tyrosinal;

Chemical Property of Carbamic acid, [(1S)-2-[4-(1,1-dimethylethoxy)phenyl]-1-formylethyl]-, 9H-fluoren-9-ylmethyl ester

Chemical Property:

• PSA: 64.63000
• LogP: 5.90350

Purity/Quality:

9H-Fluoren-9-ylmethyl N-[(2S)-1-[4-(tert-butoxy)-phenyl]-3-oxopropan-2-yl]carbamate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(1S)-2-[4-(1,1-dimethylethoxy)phenyl]-1-formylethyl]-, 9H-fluoren-9-ylmethyl ester

There total 7 articles about Carbamic acid, [(1S)-2-[4-(1,1-dimethylethoxy)phenyl]-1-formylethyl]-, 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(9H-fluoren-9-yl)methyl (S)-(1-(4-(tert-butoxy)phenyl)-3-hydroxypropan-2-yl)carbamate (187526-99-4) → (S)-(9H-fluoren-9-yl)methyl(1-(4-(tert-butoxy)phenyl)-3-oxopropan-2-yl)carbamate (154524-72-8)

Guidance literature:

With dichloro-acetic acid; dimethyl sulfoxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In toluene; at 5 - 20 ℃;

DOI:10.1016/S0960-894X(00)00458-3

Reference yield: 90.0%

Fmoc-Tyr(tBu)-N(CH3)-OCH3 (156939-66-1) → (S)-(9H-fluoren-9-yl)methyl(1-(4-(tert-butoxy)phenyl)-3-oxopropan-2-yl)carbamate (154524-72-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1021/ja046436m

Reference yield:

Dess-Martin periodane (87413-09-0) + (9H-fluoren-9-yl)methyl (S)-(1-(4-(tert-butoxy)phenyl)-3-hydroxypropan-2-yl)carbamate (187526-99-4) → α-[3-(4- O -tert-Butyl)phenyl-(S)-2- N -(9-fluorenylmethoxycarbonyl)amino]-propyl- N -ε-tert-butoxycarbonyl-L-lysyl-L-tryptophanamide + (S)-(9H-fluoren-9-yl)methyl(1-(4-(tert-butoxy)phenyl)-3-oxopropan-2-yl)carbamate (154524-72-8)

Guidance literature:

With sodium bicarbonate; sodium thiosulfate; In dichloromethane;

upstream raw materials:

Fmoc-Tyr(tBu)-N(CH₃)-OCH₃

(9H-fluoren-9-yl)methyl (S)-(1-(4-(tert-butoxy)phenyl)-3-hydroxypropan-2-yl)carbamate

Fmoc-Tyr(tBu)-OH

3-(4-tert-butoxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid benzotriazol-1-yl ester

Downstream raw materials:

C₃₄H₅₀N₈O₁₁S

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