1-benzyl 2-(tert-butyl) tetrahydro-1,2-pyridazinedicarboxylate

Base Information

• Chemical Name: 1-benzyl 2-(tert-butyl) tetrahydro-1,2-pyridazinedicarboxylate
• CAS No.: 154972-38-0
• Molecular Formula: C17H24N2O4
• Molecular Weight: 320.389
• Hs Code.: 2933990090
• Mol file: 154972-38-0.mol

Synonyms:1-benzyl 2-(tert-butyl) tetrahydro-1,2-pyridazinedicarboxylate;AB-0219;benzyl 2-(tert-butoxycarbonyl)hexahydropyridazine-1-carboxylate;1-benzyl-2-tert-butyl tetrahydropyridazine dicarboxylate;2-(tert-butoxycarbonyl)hexahydropyridazine-1-carboxylic acid benzyl ester;1-Boc-2-Cbz-hexahydropyridazine;1-t-butoxycarbonyl-2-phenylmethoxycarbonylhexahydropyridazine;

Chemical Property of 1-benzyl 2-(tert-butyl) tetrahydro-1,2-pyridazinedicarboxylate

Chemical Property:

• PSA: 59.08000
• LogP: 3.44690

Purity/Quality:

97% ^*data from raw suppliers

1-Benzyl 2-(tert-butyl) tetrahydro-1,2-pyridazinedicarboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-benzyl 2-(tert-butyl) tetrahydro-1,2-pyridazinedicarboxylate

There total 6 articles about 1-benzyl 2-(tert-butyl) tetrahydro-1,2-pyridazinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1,4-dibromo-butane (110-52-1) + 1-tert-butoxycarbonyl-2-carbobenzyloxyhydrazine (57699-88-4) → benzyl 2-(tert-butoxycarbonyl)hexahydropyridazine-1-carboxylate (154972-38-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2011.04.132

Reference yield: 93.0%

→ benzyl 2-(tert-butoxycarbonyl)hexahydropyridazine-1-carboxylate (154972-38-0) + tert-butyl tetrahydropyridazine-1(2H)-carboxylate (154972-37-9)

Guidance literature:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → benzyl 2-(tert-butoxycarbonyl)hexahydropyridazine-1-carboxylate (154972-38-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / Et₃N; DMAP / CH₂Cl₂ / 24 h

2: 32 percent / NaH / dimethylformamide / 20 °C

With dmap; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(03)00478-4

upstream raw materials:

1,4-dibromo-butane

1-tert-butoxycarbonyl-2-carbobenzyloxyhydrazine

di-tert-butyl dicarbonate

N-benzyloxycarbonyl-hydrazine

Downstream raw materials:

tetrahydropyridazine-1-carboxylic acid benzyl ester

tert-butyl tetrahydropyridazine-1(2H)-carboxylate

2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)-5,6,7,8-tetrahydropyrazolo[1,2-a]pyridazin-1-one

2-(4-fluoro-phenyl)-3-(2-methanesulfonyl-pyrimidin-4-yl)-5,6,7,8-tetrahydro-pyrazolo[1,2-a]pyridazin-1-one