1-Ethyltetralin-1-ol

Base Information

• Chemical Name: 1-Ethyltetralin-1-ol
• CAS No.: 155048-03-6
• Molecular Formula: C12H16O
• Molecular Weight: 176.258
• DSSTox Substance ID: DTXSID40436768
• Nikkaji Number: J932.931E
• Mol file: 155048-03-6.mol

Synonyms:1-Ethyltetralin-1-ol;155048-03-6;1-ethyl-1-tetralol;AGN-PC-0N0PWW;SCHEMBL6691850;DTXSID40436768

Chemical Property of 1-Ethyltetralin-1-ol

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 176.120115130
• Heavy Atom Count: 13
• Complexity: 178

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1(CCCC2=CC=CC=C21)O

Technology Process of 1-Ethyltetralin-1-ol

There total 2 articles about 1-Ethyltetralin-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

ethylmagnesium bromide (925-90-6) + methyllithium (917-54-4) + 3,4-dihydronaphthalene-1(2H)-one (529-34-0) → 1-methyl-1,2,3,4-tetrahydronaphthalen-1-ol (39202-04-5,14944-28-6) + 1-ethyl-1,2,3,4-tetrahydro-naphthalen-1-ol (155048-03-6)

Guidance literature:

ethylmagnesium bromide; methyllithium; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h;

3,4-dihydronaphthalene-1(2H)-one; In tetrahydrofuran; diethyl ether; at -78 ℃; for 5h;

DOI:10.1021/ol047685i

Reference yield: 82.0%

ethylmagnesium bromide (925-90-6) + 3,4-dihydronaphthalene-1(2H)-one (529-34-0) → 1,2,3,4-Tetrahydro-1-naphthol (529-33-9) + 1-ethyl-1,2,3,4-tetrahydro-naphthalen-1-ol (155048-03-6)

Guidance literature:

ethylmagnesium bromide; With zinc(II) chloride; In tetrahydrofuran; at 20 ℃; for 0.75h; Inert atmosphere;

3,4-dihydronaphthalene-1(2H)-one; In tetrahydrofuran; at 0 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jo100563p

Reference yield: 36.0%

1-ethyl-1,2,3,4-tetrahydro-naphthalen-1-ol (155048-03-6) → 2-(4,4-bishydroperoxy-hexyl)phenol + bis[1-hydroperoxy-1-ethyl-4-(2-hydroxyphenyl)butyl]peroxide

Guidance literature:

With sulfuric acid; dihydrogen peroxide; In water; at 0 - 20 ℃; for 72h;

DOI:10.1021/jo991457y

upstream raw materials:

ethylmagnesium bromide

methyllithium

3,4-dihydronaphthalene-1(2H)-one