2-(7-isopropyl-4-methyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)phenyl methyl ether

Base Information

• Chemical Name: 2-(7-isopropyl-4-methyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)phenyl methyl ether
• CAS No.: 155095-30-0
• Molecular Formula: C18H24N2O
• Molecular Weight: 284.39600
• Mol file: 155095-30-0.mol

Synonyms:(4R,7S)-7-Isopropyl-3-(2-methoxy-phenyl)-4-methyl-4,5,6,7-tetrahydro-1H-indazole;3-(2-methoxyphenyl)-l-menthopyrazole;

Chemical Property of 2-(7-isopropyl-4-methyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)phenyl methyl ether

Chemical Property:

• PSA: 37.91000
• LogP: 4.72220

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(7-isopropyl-4-methyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)phenyl methyl ether

There total 3 articles about 2-(7-isopropyl-4-methyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)phenyl methyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,5S)-menthone (10458-14-7,14073-97-3,17627-49-5,7786-64-3) → 3-(2'-methoxyphenyl)-l-menthopyrazole (155095-30-0)

Guidance literature:

Multi-step reaction with 2 steps

1: LDA / tetrahydrofuran

2: NH₂NH₂*H₂O; NH₂NH₂*HCl / methanol / 17 h / Heating

With hydrazine hydrochloride; hydrazine hydrate; lithium diisopropyl amide; In tetrahydrofuran; methanol; 1: Acylation / 2: Cycloaddition;

DOI:10.1002/jhet.5570370449

Reference yield:

2-Methoxybenzoyl chloride (21615-34-9) → 3-(2'-methoxyphenyl)-l-menthopyrazole (155095-30-0)

Guidance literature:

Multi-step reaction with 2 steps

1: LDA / tetrahydrofuran

2: NH₂NH₂*H₂O; NH₂NH₂*HCl / methanol / 17 h / Heating

With hydrazine hydrochloride; hydrazine hydrate; lithium diisopropyl amide; In tetrahydrofuran; methanol; 1: Acylation / 2: Cycloaddition;

DOI:10.1002/jhet.5570370449

Reference yield:

(3R,6S)-6-Isopropyl-2-(2-methoxy-benzoyl)-3-methyl-cyclohexanone (310460-67-4) → 3-(2'-methoxyphenyl)-l-menthopyrazole (155095-30-0)

Guidance literature:

With hydrogenchloride; hydrazine hydrate;

DOI:10.1016/S0040-4039(00)61417-X

upstream raw materials:

(3R,6S)-6-Isopropyl-2-(2-methoxy-benzoyl)-3-methyl-cyclohexanone

(2R,5S)-menthone

2-Methoxybenzoyl chloride

Downstream raw materials:

1-carbomethoxymethyl-3-(2'-hydroxyphenyl)-l-menthopyrazole

3-(2'-hydroxyphenyl)-l-menthopyrazole

2-carbomethoxymethyl-3-(2'-methoxyphenyl)-l-menthopyrazole

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