(R)-4-(3,4-Dichlorophenyl)-1-tetralone

Base Information

Chemical Name:(R)-4-(3,4-Dichlorophenyl)-1-tetralone
CAS No.:155748-61-1
Molecular Formula:C16H12Cl2O
Molecular Weight:291.177
Hs Code.:
UNII:HT3QM63Z52
Nikkaji Number:J1.274.584B
Wikidata:Q27280078
Mol file:155748-61-1.mol

Synonyms:155748-61-1;Sertraline ketone, (R)-;(R)-4-(3,4-Dichlorophenyl)-1-tetralone;(r)-4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1(2h)-one;(4R)-(3',4'-Dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one;(4R)-4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one;UNII-HT3QM63Z52;(R)-4-(3,4-Dichlorophenyl)-3,4-dihydro-1-naphthalenone;HT3QM63Z52;(-)-4-(3,4-Dichlorophenyl)-3,4-dihydro-1-naphthalenone;(4R)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-one;1(2H)-Naphthalenone, 4-(3,4-dichlorophenyl)-3,4-dihydro-, (4R)-;Sertraline hydrochloride specified impurity F [EP];(R)-sertraline ketone;SCHEMBL260266;(4R)-4-(3,4-Dichlorophenyl)tetralin-1-one;A899305;J-009221;Q27280078;SERTRALINE HYDROCHLORIDE IMPURITY F [EP IMPURITY];(4R)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-one

Suppliers and Price of (R)-4-(3,4-Dichlorophenyl)-1-tetralone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(4R)-(3’,4’-Dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one
10mg
$ 145.00

Crysdot
(R)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-one 95+%
1g
$ 412.00

Chemenu
(R)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-one 95%
1g
$ 389.00

American Custom Chemicals Corporation
SERTRALINE IMPURITY F 95.00%
5MG
$ 505.20

Alichem
(R)-4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1(2h)-one
1g
$ 438.00

Alichem
(R)-4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1(2h)-one
250mg
$ 185.50

Total 13 raw suppliers

Chemical Property of (R)-4-(3,4-Dichlorophenyl)-1-tetralone

Chemical Property:

Melting Point:86-88°C
PSA：17.07000
LogP:5.10180
Storage Temp.:Refrigerator
Solubility.:Benzene (Slightly), Chloroform (Slightly), Methanol (Slightly)
XLogP3:4.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:290.0265204
Heavy Atom Count:19
Complexity:344

Purity/Quality:

99%, ^*data from raw suppliers

(4R)-(3’,4’-Dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)C2=CC=CC=C2C1C3=CC(=C(C=C3)Cl)Cl
Isomeric SMILES:C1CC(=O)C2=CC=CC=C2[C@H]1C3=CC(=C(C=C3)Cl)Cl
Uses (4R)-(3’,4’-Dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one (Sertraline EP Impurity F) is an intermediate in the synthesis of the drug Sertraline.

Technology Process of (R)-4-(3,4-Dichlorophenyl)-1-tetralone

There total 35 articles about (R)-4-(3,4-Dichlorophenyl)-1-tetralone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 261776-41-4
(4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-ylidene)methylamine

: 91797-60-3
trans-(1S,4R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

: 79617-96-2
Sertraline

: 155748-61-1,79836-44-5
(4R)-(3,4-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone

Guidance literature:: With (S,S)-(ethylenebis(tetrahydroindenyl))TiF₂; phenylsilane; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1021/jo991328h

Reference yield:

: 147255-16-1
(4R)-4-(3,4-dichlorophenyl)-4-phenylbutanoic acid

: 155748-61-1,79836-44-5
(4R)-(3,4-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone

: 124379-29-9,79836-44-5
(4S)-4-(3,4-dichlorophenyl)-1-tetralone

Guidance literature:: With trifluorormethanesulfonic acid; In benzene; at 70 ℃; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1016/S0040-4020(01)88330-7

Reference yield:

: 147189-42-2
(4R)-(3,4-Dichlorophenyl)benzenebutanoic acid 1,1-dimethylethyl ester

: 155748-61-1,79836-44-5
(4R)-(3,4-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone

: 124379-29-9,79836-44-5
(4S)-4-(3,4-dichlorophenyl)-1-tetralone

Guidance literature:: With trifluorormethanesulfonic acid; In benzene; at 70 ℃; for 2h; Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1016/S0040-4020(01)88330-7