1-[alpha-(Benzoyloxymethyl)benzyloxymethyl]uracil

Base Information

• Chemical Name: 1-[alpha-(Benzoyloxymethyl)benzyloxymethyl]uracil
• CAS No.: 155831-56-4
• Molecular Formula: C20H18N2O5
• Molecular Weight: 366.373
• DSSTox Substance ID: DTXSID50435505
• Nikkaji Number: J1.815.012C
• Mol file: 155831-56-4.mol

Synonyms:CTK0E7562;155831-56-4;1-[alpha-(Benzoyloxymethyl)benzyloxymethyl]uracil;DTXSID50435505

Chemical Property of 1-[alpha-(Benzoyloxymethyl)benzyloxymethyl]uracil

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 366.12157168
• Heavy Atom Count: 27
• Complexity: 565

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(COC(=O)C2=CC=CC=C2)OCN3C=CC(=O)NC3=O

Technology Process of 1-[alpha-(Benzoyloxymethyl)benzyloxymethyl]uracil

There total 2 articles about 1-[alpha-(Benzoyloxymethyl)benzyloxymethyl]uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxy-2-phenylethyl benzoate (10335-95-2) → 1-<<(1'-phenyl-2'-benzyloxy)ethoxy>methyl>uracil (155831-56-4)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl(g) / CH₂Cl₂ / 0 °C

2: K₂CO₃ / CH₂Cl₂ / 24 h / Ambient temperature

With hydrogenchloride; potassium carbonate; In dichloromethane;

DOI:10.1002/jhet.5570310130

Reference yield:

Benzoic acid 2-chloromethoxy-2-phenyl-ethyl ester (156192-65-3) + O,O'-bis-(trimethylsilyl)uracil (10457-14-4) → 1-<<(1'-phenyl-2'-benzyloxy)ethoxy>methyl>uracil (155831-56-4)

Guidance literature:

With potassium carbonate; In dichloromethane; for 24h; Yield given; Ambient temperature;

DOI:10.1002/jhet.5570310130

Reference yield: 92.0%

1-<<(1'-phenyl-2'-benzyloxy)ethoxy>methyl>uracil (155831-56-4) → 1-<<(1'-phenyl-2'-hydroxy)ethoxy>methyl>uracil (155831-59-7)

Guidance literature:

With potassium carbonate; In methanol; Ambient temperature;

DOI:10.1002/jhet.5570310130

upstream raw materials:

Benzoic acid 2-chloromethoxy-2-phenyl-ethyl ester

O,O'-bis-(trimethylsilyl)uracil

2-hydroxy-2-phenylethyl benzoate

Downstream raw materials:

1-<<(1'-phenyl-2'-hydroxy)ethoxy>methyl>uracil

1-<<1'-phenyl-2'-(t-butyldimethylsilyloxy)ethoxy>methyl>uracil

1-<<1'-phenyl-2'(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylthio)uracil

1-<<1'-phenyl-2'-(t-butyldimethylsilyloxy)ethoxy>methyl>-6-(phenylseleno)uracil