6-[2-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine-3-carbaldehyde

Base Information

• Chemical Name: 6-[2-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine-3-carbaldehyde
• CAS No.: 157169-61-4
• Molecular Formula: C18H16N2O3
• Molecular Weight: 308.337
• DSSTox Substance ID: DTXSID90594988
• Wikidata: Q82489917
• Mol file: 157169-61-4.mol

Synonyms:157169-61-4;6-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)nicotinaldehyde;6-[2-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine-3-carbaldehyde;SCHEMBL5738837;DTXSID90594988;HDRBHTIDMNBGIY-UHFFFAOYSA-N;5-formyl-2-[2-(5-methyl-2-phenyl-4-oxazolyl) ethoxy]pyridine;5-formyl-2-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]pyridine;6-[2-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]nicotinaldehyde

Chemical Property of 6-[2-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine-3-carbaldehyde

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 308.11609238
• Heavy Atom Count: 23
• Complexity: 373

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N=C(O1)C2=CC=CC=C2)CCOC3=NC=C(C=C3)C=O

Technology Process of 6-[2-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine-3-carbaldehyde

There total 5 articles about 6-[2-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

5-iodo-2-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]pyridine → 5-formyl-2-[2-(5-methyl-2-phenyl-4-oxazolyl)-ethoxy]pyridine (157169-61-4)

Guidance literature:

With n-butyllithium; ammonium chloride; In tetrahydrofuran; hexane; nitrogen; N,N-dimethyl-formamide;

Reference yield: 72.0%

5-bromo-2-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine (784149-29-7) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-formyl-2-[2-(5-methyl-2-phenyl-4-oxazolyl)-ethoxy]pyridine (157169-61-4)

Guidance literature:

5-bromo-2-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine; With n-butyllithium; In tetrahydrofuran; diethyl ether; at -78 ℃;

N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; at 0 ℃; for 1h;

DOI:10.1016/j.bmcl.2006.08.110

Reference yield: 58.0%

5-bromo-2-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine (784149-29-7) + ammonium chloride → 5-formyl-2-[2-(5-methyl-2-phenyl-4-oxazolyl)-ethoxy]pyridine (157169-61-4)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; diethyl ether; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

5-bromo-2-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine

N,N-dimethyl-formamide

2,5-dibromopyridine

(5-methyl-2-phenyloxazol-4-yl)ethanol

Downstream raw materials:

(S)-4-Benzyl-3-((S)-2-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-ylmethyl}-tetrahydro-furan-2-carbonyl)-oxazolidin-2-one

(S)-N-((R)-2-Hydroxy-1-phenyl-ethyl)-2-methoxy-2-methyl-3-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-yl}-propionamide

1-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-ylmethyl}-cyclohexanecarboxylic acid ethyl ester

2-{6-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-ylmethyl}-tetrahydro-pyran-2-carboxylic acid ethyl ester