Toluene-4-sulfonic acid tetrahydro-furan-3-ylmethyl ester

Base Information

• Chemical Name: Toluene-4-sulfonic acid tetrahydro-furan-3-ylmethyl ester
• CAS No.: 15833-63-3
• Molecular Formula: C12H16O4S
• Molecular Weight: 256.323
• Hs Code.: 2932190090
• Mol file: 15833-63-3.mol

Synonyms:15833-63-3;Toluene-4-sulfonic acid tetrahydro-furan-3-ylmethyl ester;(tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate;oxolan-3-ylmethyl 4-methylbenzenesulfonate;(oxolan-3-yl)methyl 4-methylbenzene-1-sulfonate;MFCD20483437;tetrahydrofuran-3-ylmethyl p-toluenesulfonate;SCHEMBL2222219;Toluene-4-sulfonicacidtetrahydro-furan-3-ylmethylester;3-Furanmethanol, tetrahydro-, 3-(4-methylbenzenesulfonate);BNBVZUYOFJWGNJ-UHFFFAOYSA-N;(tetrahydro-3-furanyl)methyl tosylate;AKOS024438579;(tetrahydro-3 -furanyl)methyl tosylate;AS-37100;SY319083;EN300-100503;(3-Tetrahydrofuryl)methyl 4-Methylbenzenesulfonate;A927411;Tetrahydrofuran-3-ylmethyl 4-methylbenzenesulfonate;(tetrahydro-3-furanyl)methyl 4-methylbenzenesulfonate;rac-tetrahydrofuran-3-ylmethyl 4-methylbenzenesulfonate;Toluene-4-sulfonic acid tetrahydro-furan-3-ylmethyl ester, AldrichCPR

Chemical Property of Toluene-4-sulfonic acid tetrahydro-furan-3-ylmethyl ester

Chemical Property:

• PSA: 60.98000
• LogP: 2.81760
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 256.07693016
• Heavy Atom Count: 17
• Complexity: 325

Purity/Quality:

97% ^*data from raw suppliers

Toluene-4-sulfonic acid tetrahydro-furan-3-ylmethyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)OCC2CCOC2

Technology Process of Toluene-4-sulfonic acid tetrahydro-furan-3-ylmethyl ester

There total 4 articles about Toluene-4-sulfonic acid tetrahydro-furan-3-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-tetrahydrofuranmethanol (124391-75-9,124506-31-6,15833-61-1) + p-toluenesulfonyl chloride (98-59-9) → (tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate (15833-63-3)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 3.25h;

Reference yield:

3-tetrahydrofuranmethanol (124391-75-9,124506-31-6,15833-61-1) + p-toluenesulfonyl chloride (98-59-9) → (tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate (15833-63-3) + [(Tetrahydro-3-furanyl)methyl]p-toluenesulfonate

Guidance literature:

With triethylamine; In tetrahydrofuran; hexane; acetone;

Reference yield:

tetrahydro-3-furanomethanol + 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran (96042-30-7) + p-toluenesulfonyl chloride (98-59-9) → (tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate (15833-63-3)

Guidance literature:

With hydrogenchloride; In pyridine;

upstream raw materials:

3-tetrahydrofuranmethanol

p-toluenesulfonyl chloride

4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

Downstream raw materials:

3-iodomethyl-tetrahydro-furan

3-tert-butyl-1-((tetrahydrofuran-3-yl)methyl)-N-trityl-1H-pyrazol-5-amine

5-chloro-N-[(2Z)-5,5-dimethyl-3-(tetrahydrofuran-3-ylmethyl)-1,3-thiazolidin-2-ylidene]-2-methoxybenzamide

(+/-)-(tetrahydrofuran-3-yl)methanamine hydrochloride