6-Bromomethyl-nicotinonitrile

Base Information

• Chemical Name: 6-Bromomethyl-nicotinonitrile
• CAS No.: 158626-15-4
• Molecular Formula: C7H5BrN2
• Molecular Weight: 197.034
• Hs Code.: 2933399090
• Mol file: 158626-15-4.mol

Synonyms:6-Bromomethyl-nicotinonitrile;

Chemical Property of 6-Bromomethyl-nicotinonitrile

Chemical Property:

• Boiling Point: 286.459 °C at 760 mmHg
• PKA: 0.00±0.22(Predicted)
• Flash Point: 127.046 °C
• PSA: 36.68000
• Density: 1.607 g/cm³
• LogP: 1.84818
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

6-(Bromomethyl)nicotinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-(Bromomethyl)nicotinonitrile has been used as a reactant in the synthesis of oxadiazoles as selective S1P receptor agonists that may be used in the treatment of relapsing forms of MS.

Technology Process of 6-Bromomethyl-nicotinonitrile

There total 2 articles about 6-Bromomethyl-nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

6-methylnicotinonitrile (3222-48-8) → 2-bromomethyl-5-cyanopyridine (158626-15-4)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In 1,2-dichloro-ethane; at 80 ℃; for 3.5 - 6h;

Reference yield:

→ 2-bromomethyl-5-cyanopyridine (158626-15-4)

Guidance literature:

Reference yield: 91.7%

2-bromo-5-hydroxybenzaldehyde (2973-80-0) + 2-bromomethyl-5-cyanopyridine (158626-15-4) → C14H9BrN2O2

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2.5h; Inert atmosphere;

upstream raw materials:

6-methylnicotinonitrile

Downstream raw materials:

6-(((3-bromo-4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy)methyl)nicotinonitrile

(S)-4-chloro-N-((5-cyanopyridin-2-yl)methyl)-N-(1-phenylpropyl)benzenesulfonamide

4-chloro-N-((5-cyanopyridin-2-yl)methyl)-N-(pentan-3-yl)benzenesulfonamide

N-(1-((5-cyanopyridin-2-yl)methyl)-1H-pyrazol-3-yl)-2-(4-(1-(trifluoromethyl)cyclopropyl)phenyl)acetamide